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Case report: Mycobacterium neoaurum infection during ICI therapy in a hepatocellular carcinoma patient with psoriasis

We report here a patient with advanced hepatocellular carcinoma (HCC) and psoriasis treated with immune checkpoint inhibitor (ICI) therapy who experienced tumor partial response and psoriatic exacerbation. Meanwhile, the patient contracted mycobacterium neoaurum during the treatment period, while it...

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Autores principales: Pang, Ling, Chen, Zhongju, Xu, Dong, Cheng, Weiting
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9441546/
https://www.ncbi.nlm.nih.gov/pubmed/36072586
http://dx.doi.org/10.3389/fimmu.2022.972302
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author Pang, Ling
Chen, Zhongju
Xu, Dong
Cheng, Weiting
author_facet Pang, Ling
Chen, Zhongju
Xu, Dong
Cheng, Weiting
author_sort Pang, Ling
collection PubMed
description We report here a patient with advanced hepatocellular carcinoma (HCC) and psoriasis treated with immune checkpoint inhibitor (ICI) therapy who experienced tumor partial response and psoriatic exacerbation. Meanwhile, the patient contracted mycobacterium neoaurum during the treatment period, while it was an opportunistic infection and mainly happened in immunosuppressed patients. We discussed the possibility that this infection was an ICI-associated infection independent of immunosuppression due to dysregulated immunity, which was the result of the effects of immunotherapy and autoimmune disease (AID), and the characteristics and treatment of M. neoaurum, which was rarely reported in China. This case highlights the fact that some infections can be precipitated by ICIs in the absence of immunosuppressive treatment, especially the patients with AID.
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spelling pubmed-94415462022-09-06 Case report: Mycobacterium neoaurum infection during ICI therapy in a hepatocellular carcinoma patient with psoriasis Pang, Ling Chen, Zhongju Xu, Dong Cheng, Weiting Front Immunol Immunology We report here a patient with advanced hepatocellular carcinoma (HCC) and psoriasis treated with immune checkpoint inhibitor (ICI) therapy who experienced tumor partial response and psoriatic exacerbation. Meanwhile, the patient contracted mycobacterium neoaurum during the treatment period, while it was an opportunistic infection and mainly happened in immunosuppressed patients. We discussed the possibility that this infection was an ICI-associated infection independent of immunosuppression due to dysregulated immunity, which was the result of the effects of immunotherapy and autoimmune disease (AID), and the characteristics and treatment of M. neoaurum, which was rarely reported in China. This case highlights the fact that some infections can be precipitated by ICIs in the absence of immunosuppressive treatment, especially the patients with AID. Frontiers Media S.A. 2022-08-22 /pmc/articles/PMC9441546/ /pubmed/36072586 http://dx.doi.org/10.3389/fimmu.2022.972302 Text en Copyright © 2022 Pang, Chen, Xu and Cheng https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Pang, Ling
Chen, Zhongju
Xu, Dong
Cheng, Weiting
Case report: Mycobacterium neoaurum infection during ICI therapy in a hepatocellular carcinoma patient with psoriasis
title Case report: Mycobacterium neoaurum infection during ICI therapy in a hepatocellular carcinoma patient with psoriasis
title_full Case report: Mycobacterium neoaurum infection during ICI therapy in a hepatocellular carcinoma patient with psoriasis
title_fullStr Case report: Mycobacterium neoaurum infection during ICI therapy in a hepatocellular carcinoma patient with psoriasis
title_full_unstemmed Case report: Mycobacterium neoaurum infection during ICI therapy in a hepatocellular carcinoma patient with psoriasis
title_short Case report: Mycobacterium neoaurum infection during ICI therapy in a hepatocellular carcinoma patient with psoriasis
title_sort case report: mycobacterium neoaurum infection during ici therapy in a hepatocellular carcinoma patient with psoriasis
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9441546/
https://www.ncbi.nlm.nih.gov/pubmed/36072586
http://dx.doi.org/10.3389/fimmu.2022.972302
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