Megakaryopoiesis impairment through acute innate immune signaling activation by azacitidine

Thrombocytopenia, prevalent in the majority of patients with myeloid malignancies, such as myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML), is an independent adverse prognostic factor. Azacitidine (AZA), a mainstay therapeutic agent for stem cell transplant–ineligible patients with MD...

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Detalles Bibliográficos
Autores principales: Okoye-Okafor, Ujunwa Cynthia, Javarappa, Komal K., Tsallos, Dimitrios, Saad, Joseph, Yang, Daozheng, Zhang, Chi, Benard, Lumie, Thiruthuvanathan, Victor J., Cole, Sally, Ruiz, Stephen, Tatiparthy, Madhuri, Choudhary, Gaurav, DeFronzo, Stefanie, Bartholdy, Boris A., Pallaud, Celine, Ramos, Pedro Marques, Shastri, Aditi, Verma, Amit, Heckman, Caroline A., Will, Britta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9441716/
https://www.ncbi.nlm.nih.gov/pubmed/36053753
http://dx.doi.org/10.1084/jem.20212228

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