Cargando…
Emerging roles of ferroptosis in glioma
Glioma is the most common primary malignant tumor in the central nervous system, and directly affects the quality of life and cognitive function of patients. Ferroptosis, is a new form of regulated cell death characterized by iron-dependent lipid peroxidation. Ferroptosis is mainly due to redox imba...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9441765/ https://www.ncbi.nlm.nih.gov/pubmed/36072803 http://dx.doi.org/10.3389/fonc.2022.993316 |
_version_ | 1784782657459060736 |
---|---|
author | Shi, Jiaqi Yang, Ning Han, Mingzhi Qiu, Chen |
author_facet | Shi, Jiaqi Yang, Ning Han, Mingzhi Qiu, Chen |
author_sort | Shi, Jiaqi |
collection | PubMed |
description | Glioma is the most common primary malignant tumor in the central nervous system, and directly affects the quality of life and cognitive function of patients. Ferroptosis, is a new form of regulated cell death characterized by iron-dependent lipid peroxidation. Ferroptosis is mainly due to redox imbalance and involves multiple intracellular biology processes, such as iron metabolism, lipid metabolism, and antioxidants synthesis. Induction of ferroptosis could be a new target for glioma treatment, and ferroptosis-related processes are associated with chemoresistance and radioresistance in glioma. In the present review, we provide the characteristics, key regulators and pathways of ferroptosis and the crosstalk between ferroptosis and other programmed cell death in glioma, we also proposed the application and prospect of ferroptosis in the treatment of glioma. |
format | Online Article Text |
id | pubmed-9441765 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-94417652022-09-06 Emerging roles of ferroptosis in glioma Shi, Jiaqi Yang, Ning Han, Mingzhi Qiu, Chen Front Oncol Oncology Glioma is the most common primary malignant tumor in the central nervous system, and directly affects the quality of life and cognitive function of patients. Ferroptosis, is a new form of regulated cell death characterized by iron-dependent lipid peroxidation. Ferroptosis is mainly due to redox imbalance and involves multiple intracellular biology processes, such as iron metabolism, lipid metabolism, and antioxidants synthesis. Induction of ferroptosis could be a new target for glioma treatment, and ferroptosis-related processes are associated with chemoresistance and radioresistance in glioma. In the present review, we provide the characteristics, key regulators and pathways of ferroptosis and the crosstalk between ferroptosis and other programmed cell death in glioma, we also proposed the application and prospect of ferroptosis in the treatment of glioma. Frontiers Media S.A. 2022-08-22 /pmc/articles/PMC9441765/ /pubmed/36072803 http://dx.doi.org/10.3389/fonc.2022.993316 Text en Copyright © 2022 Shi, Yang, Han and Qiu https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Shi, Jiaqi Yang, Ning Han, Mingzhi Qiu, Chen Emerging roles of ferroptosis in glioma |
title | Emerging roles of ferroptosis in glioma |
title_full | Emerging roles of ferroptosis in glioma |
title_fullStr | Emerging roles of ferroptosis in glioma |
title_full_unstemmed | Emerging roles of ferroptosis in glioma |
title_short | Emerging roles of ferroptosis in glioma |
title_sort | emerging roles of ferroptosis in glioma |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9441765/ https://www.ncbi.nlm.nih.gov/pubmed/36072803 http://dx.doi.org/10.3389/fonc.2022.993316 |
work_keys_str_mv | AT shijiaqi emergingrolesofferroptosisinglioma AT yangning emergingrolesofferroptosisinglioma AT hanmingzhi emergingrolesofferroptosisinglioma AT qiuchen emergingrolesofferroptosisinglioma |