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Case report: The first description of a Dieulafoy's lesion in the gastric mucosa of a dog

An approximately 12-year-old, 31 kg, male neutered Labrador Retriever was presented to the referring hospital with an acute onset (less than 1 day) of hematemesis and melena. The dog was treated supportively for a presumptive gastric ulcer for 4 days with intravenous fluids, gastro protectants, such...

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Autores principales: Barrantes Murillo, Daniel Felipe, Tillson, Michael, Koehler, Jennifer W., Sandey, Maninder
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9441867/
https://www.ncbi.nlm.nih.gov/pubmed/36072394
http://dx.doi.org/10.3389/fvets.2022.932435
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author Barrantes Murillo, Daniel Felipe
Tillson, Michael
Koehler, Jennifer W.
Sandey, Maninder
author_facet Barrantes Murillo, Daniel Felipe
Tillson, Michael
Koehler, Jennifer W.
Sandey, Maninder
author_sort Barrantes Murillo, Daniel Felipe
collection PubMed
description An approximately 12-year-old, 31 kg, male neutered Labrador Retriever was presented to the referring hospital with an acute onset (less than 1 day) of hematemesis and melena. The dog was treated supportively for a presumptive gastric ulcer for 4 days with intravenous fluids, gastro protectants, such as pantoprazole, misoprostol, sucralfate, and barium, as well as an anti-emetic (maropitant) and analgesics (fentanyl, gabapentin, and tramadol). Throughout medical management, the dog continued to require blood transfusions approximately every 24 h. Given the poor medical response, the patient was subjected to an exploratory laparotomy. During surgery, a grossly raised, blister-like lesion on the mucosal surface of the stomach was appreciated on the lesser curvature of the stomach. A partial gastrectomy was performed, and the segment was submitted for histological evaluation. Histologically, there were multiple, tortuous, medium-caliber muscular arteries (>1.0 mm in diameter) in the submucosa. A single large-caliber artery (>0.75 mm in diameter) containing a partially occlusive thrombus extruded through the mucosa and projected on the ulcerated surface. The patient's signs were similar clinically and histopathologically to Dieulafoy's lesion in people. A Dieulafoy's lesion is a potentially life-threatening disorder that causes gastrointestinal (GI) hemorrhage. This lesion is characterized by a dilated, large-caliber, aberrant submucosal artery that erodes through the epithelium and ruptures, resulting in massive and potentially fatal hemorrhage. This lesion has never been documented previously in a dog.
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spelling pubmed-94418672022-09-06 Case report: The first description of a Dieulafoy's lesion in the gastric mucosa of a dog Barrantes Murillo, Daniel Felipe Tillson, Michael Koehler, Jennifer W. Sandey, Maninder Front Vet Sci Veterinary Science An approximately 12-year-old, 31 kg, male neutered Labrador Retriever was presented to the referring hospital with an acute onset (less than 1 day) of hematemesis and melena. The dog was treated supportively for a presumptive gastric ulcer for 4 days with intravenous fluids, gastro protectants, such as pantoprazole, misoprostol, sucralfate, and barium, as well as an anti-emetic (maropitant) and analgesics (fentanyl, gabapentin, and tramadol). Throughout medical management, the dog continued to require blood transfusions approximately every 24 h. Given the poor medical response, the patient was subjected to an exploratory laparotomy. During surgery, a grossly raised, blister-like lesion on the mucosal surface of the stomach was appreciated on the lesser curvature of the stomach. A partial gastrectomy was performed, and the segment was submitted for histological evaluation. Histologically, there were multiple, tortuous, medium-caliber muscular arteries (>1.0 mm in diameter) in the submucosa. A single large-caliber artery (>0.75 mm in diameter) containing a partially occlusive thrombus extruded through the mucosa and projected on the ulcerated surface. The patient's signs were similar clinically and histopathologically to Dieulafoy's lesion in people. A Dieulafoy's lesion is a potentially life-threatening disorder that causes gastrointestinal (GI) hemorrhage. This lesion is characterized by a dilated, large-caliber, aberrant submucosal artery that erodes through the epithelium and ruptures, resulting in massive and potentially fatal hemorrhage. This lesion has never been documented previously in a dog. Frontiers Media S.A. 2022-08-22 /pmc/articles/PMC9441867/ /pubmed/36072394 http://dx.doi.org/10.3389/fvets.2022.932435 Text en Copyright © 2022 Barrantes Murillo, Tillson, Koehler and Sandey. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Veterinary Science
Barrantes Murillo, Daniel Felipe
Tillson, Michael
Koehler, Jennifer W.
Sandey, Maninder
Case report: The first description of a Dieulafoy's lesion in the gastric mucosa of a dog
title Case report: The first description of a Dieulafoy's lesion in the gastric mucosa of a dog
title_full Case report: The first description of a Dieulafoy's lesion in the gastric mucosa of a dog
title_fullStr Case report: The first description of a Dieulafoy's lesion in the gastric mucosa of a dog
title_full_unstemmed Case report: The first description of a Dieulafoy's lesion in the gastric mucosa of a dog
title_short Case report: The first description of a Dieulafoy's lesion in the gastric mucosa of a dog
title_sort case report: the first description of a dieulafoy's lesion in the gastric mucosa of a dog
topic Veterinary Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9441867/
https://www.ncbi.nlm.nih.gov/pubmed/36072394
http://dx.doi.org/10.3389/fvets.2022.932435
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