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Pharmacokinetics of baicalin and oroxyloside in plasma and different tissues of rats after transnasal aerosol inhalation and intravenous injection of Tanreqing

To avoid adverse drug reactions associated with injection, off-label nebulization of Tanreqing (TRQ) injection is often used in China to treat respiratory diseases. However, the aerodynamic properties and lung availability of TRQ aerosols remain largely uninvestigated. This study aimed to investigat...

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Autores principales: Chen, Teng-Fei, Song, Ling, Gao, Yun-Hang, Li, Han, Li, Jian-Liang, Hou, Hong-Ping, Peng, Bo, Wang, Hui-Ying, Cheng, Wen-Hao, Ye, Zu-Guang, Li, Ying-Fei, Zhang, Guang-Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9442038/
https://www.ncbi.nlm.nih.gov/pubmed/36071852
http://dx.doi.org/10.3389/fphar.2022.951613
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author Chen, Teng-Fei
Song, Ling
Gao, Yun-Hang
Li, Han
Li, Jian-Liang
Hou, Hong-Ping
Peng, Bo
Wang, Hui-Ying
Cheng, Wen-Hao
Ye, Zu-Guang
Li, Ying-Fei
Zhang, Guang-Ping
author_facet Chen, Teng-Fei
Song, Ling
Gao, Yun-Hang
Li, Han
Li, Jian-Liang
Hou, Hong-Ping
Peng, Bo
Wang, Hui-Ying
Cheng, Wen-Hao
Ye, Zu-Guang
Li, Ying-Fei
Zhang, Guang-Ping
author_sort Chen, Teng-Fei
collection PubMed
description To avoid adverse drug reactions associated with injection, off-label nebulization of Tanreqing (TRQ) injection is often used in China to treat respiratory diseases. However, the aerodynamic properties and lung availability of TRQ aerosols remain largely uninvestigated. This study aimed to investigate the size distribution of TRQ aerosols and to compare the pharmacokinetics and tissue distribution of two compounds from TRQ (baicalin and oroxyloside) after transnasal aerosol inhalation and intravenous administration. Furthermore, this study aimed to evaluate the efficacy of TRQ against lipopolysaccharide-induced lung inflammation. The Dv(50) and transmission of TRQ aerosols were 2.512 μm and 74.867%, respectively. The C(max) of baicalin and oroxyloside in rat plasma after inhalation was lower than that after intravenous injection. After inhalation, the area under the curve (AUC) of baicalin and oroxyloside in tissues (lung, bronchoalveolar lavage fluid, and trachea) was 7.9–115.3 and 9.5–16.0 times that observed after intravenous administration, respectively. Baicalin and oroxyloside maintained high concentrations 4 h after inhalation, but only 1 h after intravenous injection. The mean lung-to-plasma concentration ratios of baicalin and oroxyloside were 287.6 and 49.9 times higher than with intravenous administration. Inhaled TRQ achieved the same effect against lipopolysaccharide-induced lung inflammation in mice at doses of only 1/16–1/8 of those administered intravenously. The results indicate that TRQ inhalation is a promising alternative to intravenous injections for the treatment of respiratory infection.
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spelling pubmed-94420382022-09-06 Pharmacokinetics of baicalin and oroxyloside in plasma and different tissues of rats after transnasal aerosol inhalation and intravenous injection of Tanreqing Chen, Teng-Fei Song, Ling Gao, Yun-Hang Li, Han Li, Jian-Liang Hou, Hong-Ping Peng, Bo Wang, Hui-Ying Cheng, Wen-Hao Ye, Zu-Guang Li, Ying-Fei Zhang, Guang-Ping Front Pharmacol Pharmacology To avoid adverse drug reactions associated with injection, off-label nebulization of Tanreqing (TRQ) injection is often used in China to treat respiratory diseases. However, the aerodynamic properties and lung availability of TRQ aerosols remain largely uninvestigated. This study aimed to investigate the size distribution of TRQ aerosols and to compare the pharmacokinetics and tissue distribution of two compounds from TRQ (baicalin and oroxyloside) after transnasal aerosol inhalation and intravenous administration. Furthermore, this study aimed to evaluate the efficacy of TRQ against lipopolysaccharide-induced lung inflammation. The Dv(50) and transmission of TRQ aerosols were 2.512 μm and 74.867%, respectively. The C(max) of baicalin and oroxyloside in rat plasma after inhalation was lower than that after intravenous injection. After inhalation, the area under the curve (AUC) of baicalin and oroxyloside in tissues (lung, bronchoalveolar lavage fluid, and trachea) was 7.9–115.3 and 9.5–16.0 times that observed after intravenous administration, respectively. Baicalin and oroxyloside maintained high concentrations 4 h after inhalation, but only 1 h after intravenous injection. The mean lung-to-plasma concentration ratios of baicalin and oroxyloside were 287.6 and 49.9 times higher than with intravenous administration. Inhaled TRQ achieved the same effect against lipopolysaccharide-induced lung inflammation in mice at doses of only 1/16–1/8 of those administered intravenously. The results indicate that TRQ inhalation is a promising alternative to intravenous injections for the treatment of respiratory infection. Frontiers Media S.A. 2022-08-22 /pmc/articles/PMC9442038/ /pubmed/36071852 http://dx.doi.org/10.3389/fphar.2022.951613 Text en Copyright © 2022 Chen, Song, Gao, Li, Li, Hou, Peng, Wang, Cheng, Ye, Li and Zhang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Chen, Teng-Fei
Song, Ling
Gao, Yun-Hang
Li, Han
Li, Jian-Liang
Hou, Hong-Ping
Peng, Bo
Wang, Hui-Ying
Cheng, Wen-Hao
Ye, Zu-Guang
Li, Ying-Fei
Zhang, Guang-Ping
Pharmacokinetics of baicalin and oroxyloside in plasma and different tissues of rats after transnasal aerosol inhalation and intravenous injection of Tanreqing
title Pharmacokinetics of baicalin and oroxyloside in plasma and different tissues of rats after transnasal aerosol inhalation and intravenous injection of Tanreqing
title_full Pharmacokinetics of baicalin and oroxyloside in plasma and different tissues of rats after transnasal aerosol inhalation and intravenous injection of Tanreqing
title_fullStr Pharmacokinetics of baicalin and oroxyloside in plasma and different tissues of rats after transnasal aerosol inhalation and intravenous injection of Tanreqing
title_full_unstemmed Pharmacokinetics of baicalin and oroxyloside in plasma and different tissues of rats after transnasal aerosol inhalation and intravenous injection of Tanreqing
title_short Pharmacokinetics of baicalin and oroxyloside in plasma and different tissues of rats after transnasal aerosol inhalation and intravenous injection of Tanreqing
title_sort pharmacokinetics of baicalin and oroxyloside in plasma and different tissues of rats after transnasal aerosol inhalation and intravenous injection of tanreqing
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9442038/
https://www.ncbi.nlm.nih.gov/pubmed/36071852
http://dx.doi.org/10.3389/fphar.2022.951613
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