Role of Pannexin-1-P2X7R signaling on cell death and pro-inflammatory mediator expression induced by Clostridioides difficile toxins in enteric glia

Clostridioides difficile (C. difficile) produces toxins A (TcdA) and B (TcdB), both associated with intestinal damage and diarrhea. Pannexin-1 (Panx1) channels allows the passage of messenger molecules, such as adenosine triphosphate (ATP), which in turn activate the P2X7 receptors (P2X7R) that regu...

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Detalles Bibliográficos
Autores principales: Loureiro, Andrea V., Moura-Neto, Lauro I., Martins, Conceição S., Silva, Pedro I. M., Lopes, Matheus B.S., Leitão, Renata F. C., Coelho-Aguiar, Juliana M., Moura-Neto, Vivaldo, Warren, Cirle A., Costa, Deiziane V.S., Brito, Gerly A. C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9442043/
https://www.ncbi.nlm.nih.gov/pubmed/36072579
http://dx.doi.org/10.3389/fimmu.2022.956340

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