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Immunohistochemical searching for estrogen and progesterone receptors in women vocal fold epithelia

Larynx is extremely sensitive to endocrinologic changes. Most vocal fold mucosa alterations are caused by changes in vocal fold liquid content and its epithelial changes. Estrogen and progesterone interfere and change this liquid content in the vocal folds. Our goal with the present paper is to stud...

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Autores principales: Rios, Oswaldo Angel Bellido, de Campos Duprat, Andre, dos Santos, Adriana Ribeiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9442059/
https://www.ncbi.nlm.nih.gov/pubmed/18852972
http://dx.doi.org/10.1016/S1808-8694(15)30593-0
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author Rios, Oswaldo Angel Bellido
de Campos Duprat, Andre
dos Santos, Adriana Ribeiro
author_facet Rios, Oswaldo Angel Bellido
de Campos Duprat, Andre
dos Santos, Adriana Ribeiro
author_sort Rios, Oswaldo Angel Bellido
collection PubMed
description Larynx is extremely sensitive to endocrinologic changes. Most vocal fold mucosa alterations are caused by changes in vocal fold liquid content and its epithelial changes. Estrogen and progesterone interfere and change this liquid content in the vocal folds. Our goal with the present paper is to study the presence of estrogen and progesterone receptors on vocal fold epithelium in 19 vocal fold epithelium specimens that did not present any indication of disease, especially inflammatory disease. We discarded those cases of patients above 40 years of age and those below 15. RESULTS: we found progesterone receptors in 18 of the 19 patients. The progesterone receptors are located both in the nucleus and the cytoplasm of cells, and mainly in the basal layer. There was no report of estrogen receptors present in the vocal folds. CONCLUSION: Vocal fold epithelium bears progesterone receptors, in the cytoplasm and in the nucleus. We did not find estrogen receptors in the epithelia of the vocal folds investigated.
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spelling pubmed-94420592022-09-09 Immunohistochemical searching for estrogen and progesterone receptors in women vocal fold epithelia Rios, Oswaldo Angel Bellido de Campos Duprat, Andre dos Santos, Adriana Ribeiro Braz J Otorhinolaryngol Original Article Larynx is extremely sensitive to endocrinologic changes. Most vocal fold mucosa alterations are caused by changes in vocal fold liquid content and its epithelial changes. Estrogen and progesterone interfere and change this liquid content in the vocal folds. Our goal with the present paper is to study the presence of estrogen and progesterone receptors on vocal fold epithelium in 19 vocal fold epithelium specimens that did not present any indication of disease, especially inflammatory disease. We discarded those cases of patients above 40 years of age and those below 15. RESULTS: we found progesterone receptors in 18 of the 19 patients. The progesterone receptors are located both in the nucleus and the cytoplasm of cells, and mainly in the basal layer. There was no report of estrogen receptors present in the vocal folds. CONCLUSION: Vocal fold epithelium bears progesterone receptors, in the cytoplasm and in the nucleus. We did not find estrogen receptors in the epithelia of the vocal folds investigated. Elsevier 2015-10-18 /pmc/articles/PMC9442059/ /pubmed/18852972 http://dx.doi.org/10.1016/S1808-8694(15)30593-0 Text en . https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Original Article
Rios, Oswaldo Angel Bellido
de Campos Duprat, Andre
dos Santos, Adriana Ribeiro
Immunohistochemical searching for estrogen and progesterone receptors in women vocal fold epithelia
title Immunohistochemical searching for estrogen and progesterone receptors in women vocal fold epithelia
title_full Immunohistochemical searching for estrogen and progesterone receptors in women vocal fold epithelia
title_fullStr Immunohistochemical searching for estrogen and progesterone receptors in women vocal fold epithelia
title_full_unstemmed Immunohistochemical searching for estrogen and progesterone receptors in women vocal fold epithelia
title_short Immunohistochemical searching for estrogen and progesterone receptors in women vocal fold epithelia
title_sort immunohistochemical searching for estrogen and progesterone receptors in women vocal fold epithelia
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9442059/
https://www.ncbi.nlm.nih.gov/pubmed/18852972
http://dx.doi.org/10.1016/S1808-8694(15)30593-0
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