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Immunological evaluation of vestibular folds in autopsies of patients with the Acquired Immunodeficiency Syndrome
Immune response cells are decreased in patients with the Acquired Immunodeficiency Syndrome. This alters the cell population in vestibular fold lymphoid follicles, leading to respiratory infections in these patients. Such infections are the main cause of mortality and morbidity in these patients. AI...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9442104/ https://www.ncbi.nlm.nih.gov/pubmed/18661009 http://dx.doi.org/10.1016/S1808-8694(15)30569-3 |
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author | Olegário, Janaínna Grazielle Pacheco Rossi, Renata Calciolari Salge, Ana Karina Marques Corrêa, Rosana Rosa Miranda de Paula Antunes Teixeira, Vicente da Cunha Castro, Eumenia Costa |
author_facet | Olegário, Janaínna Grazielle Pacheco Rossi, Renata Calciolari Salge, Ana Karina Marques Corrêa, Rosana Rosa Miranda de Paula Antunes Teixeira, Vicente da Cunha Castro, Eumenia Costa |
author_sort | Olegário, Janaínna Grazielle Pacheco |
collection | PubMed |
description | Immune response cells are decreased in patients with the Acquired Immunodeficiency Syndrome. This alters the cell population in vestibular fold lymphoid follicles, leading to respiratory infections in these patients. Such infections are the main cause of mortality and morbidity in these patients. AIM: to characterize lymphoid follicle cell populations in the vestibular folds of adults with the Acquired Immunodeficiency Syndrome and associated or not respiratory infection. MATERIALS AND METHODS: A retrospective study was made of 64 adult larynges harvested during routine autopsies. Anti-B cell, Anti-CD3, Anti-CD68 and Anti-follicular dendritic cell antibodies were used for immunological testing. RESULTS: 46 (71.87%) of the sample patients had the Acquired Immunodeficiency Syndrome. In these patients, lymphoid follicle cellularity was lower compared to the control group. The cell number was decreased in patients with the Acquired Immunodefficiency Syndrome and associated respiratory tract infection. CONCLUSION: We demonstrated in this study that vestibular fold lymphoid follicles were affected by viral infections, and may be considered as a reliable marker of immunodepression in these patients. |
format | Online Article Text |
id | pubmed-9442104 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-94421042022-09-09 Immunological evaluation of vestibular folds in autopsies of patients with the Acquired Immunodeficiency Syndrome Olegário, Janaínna Grazielle Pacheco Rossi, Renata Calciolari Salge, Ana Karina Marques Corrêa, Rosana Rosa Miranda de Paula Antunes Teixeira, Vicente da Cunha Castro, Eumenia Costa Braz J Otorhinolaryngol Original Article Immune response cells are decreased in patients with the Acquired Immunodeficiency Syndrome. This alters the cell population in vestibular fold lymphoid follicles, leading to respiratory infections in these patients. Such infections are the main cause of mortality and morbidity in these patients. AIM: to characterize lymphoid follicle cell populations in the vestibular folds of adults with the Acquired Immunodeficiency Syndrome and associated or not respiratory infection. MATERIALS AND METHODS: A retrospective study was made of 64 adult larynges harvested during routine autopsies. Anti-B cell, Anti-CD3, Anti-CD68 and Anti-follicular dendritic cell antibodies were used for immunological testing. RESULTS: 46 (71.87%) of the sample patients had the Acquired Immunodeficiency Syndrome. In these patients, lymphoid follicle cellularity was lower compared to the control group. The cell number was decreased in patients with the Acquired Immunodefficiency Syndrome and associated respiratory tract infection. CONCLUSION: We demonstrated in this study that vestibular fold lymphoid follicles were affected by viral infections, and may be considered as a reliable marker of immunodepression in these patients. Elsevier 2015-10-19 /pmc/articles/PMC9442104/ /pubmed/18661009 http://dx.doi.org/10.1016/S1808-8694(15)30569-3 Text en . https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Original Article Olegário, Janaínna Grazielle Pacheco Rossi, Renata Calciolari Salge, Ana Karina Marques Corrêa, Rosana Rosa Miranda de Paula Antunes Teixeira, Vicente da Cunha Castro, Eumenia Costa Immunological evaluation of vestibular folds in autopsies of patients with the Acquired Immunodeficiency Syndrome |
title | Immunological evaluation of vestibular folds in autopsies of patients with the Acquired Immunodeficiency Syndrome |
title_full | Immunological evaluation of vestibular folds in autopsies of patients with the Acquired Immunodeficiency Syndrome |
title_fullStr | Immunological evaluation of vestibular folds in autopsies of patients with the Acquired Immunodeficiency Syndrome |
title_full_unstemmed | Immunological evaluation of vestibular folds in autopsies of patients with the Acquired Immunodeficiency Syndrome |
title_short | Immunological evaluation of vestibular folds in autopsies of patients with the Acquired Immunodeficiency Syndrome |
title_sort | immunological evaluation of vestibular folds in autopsies of patients with the acquired immunodeficiency syndrome |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9442104/ https://www.ncbi.nlm.nih.gov/pubmed/18661009 http://dx.doi.org/10.1016/S1808-8694(15)30569-3 |
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