Membrane anchored IL-18 linked to constitutively active TLR4 and CD40 improves human T cell antitumor capacities for adoptive cell therapy

BACKGROUND: Adoptive transfer of tumor-infiltrating lymphocytes (TILs) or blood T cells genetically redirected by an antitumor TCR or CAR induces a strong antitumor response in a proportion of patients with cancer; however, the therapeutic efficacy is often limited by rapid decline in T cell functio...

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Detalles Bibliográficos
Autores principales: Blokon-Kogan, Dayana, Levi-Mann, Maya, Malka-Levy, Lior, Itzhaki, Orit, Besser, Michal J, Shiftan, Yuval, Szöőr, Árpád, Vereb, György, Gross, Gideon, Abken, Hinrich, Weinstein-Marom, Hadas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2022
Materias:
Immune Cell Therapies and Immune Cell Engineering
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9442493/
http://dx.doi.org/10.1136/jitc-2020-001544

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9442493/
http://dx.doi.org/10.1136/jitc-2020-001544

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