Dipeptidyl peptidase-1 inhibition in patients hospitalised with COVID-19: a multicentre, double-blind, randomised, parallel-group, placebo-controlled trial

BACKGROUND: Neutrophil serine proteases are involved in the pathogenesis of COVID-19 and increased serine protease activity has been reported in severe and fatal infection. We investigated whether brensocatib, an inhibitor of dipeptidyl peptidase-1 (DPP-1; an enzyme responsible for the activation of...

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Autores principales: Keir, Holly R, Long, Merete B, Abo-Leyah, Hani, Giam, Yan Hui, Vadiveloo, Thenmalar, Pembridge, Thomas, Hull, Rebecca C, Delgado, Lilia, Band, Margaret, McLaren-Neil, Fiona, Adamson, Simon, Lahnsteiner, Eva, Gilmour, Amy, Hughes, Chloe, New, Benjamin JM, Connell, David, Dowey, Rebecca, Turton, Helena, Richardson, Hollian, Cassidy, Diane, Cooper, Jamie, Suntharalingam, Jay, Diwakar, Lavanya, Russell, Peter, Underwood, Jonathan, Hicks, Alexander, Dosanjh, Davinder PS, Sage, Beth, Dhasmana, Devesh, Spears, Mark, Thompson, AA Roger, Brightling, Christopher, Smith, Andrew, Patel, Manish, George, Jacob, Condliffe, Alison M, Shoemark, Amelia, MacLennan, Graeme, Chalmers, James D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Author(s). Published by Elsevier Ltd. 2022
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9442496/
https://www.ncbi.nlm.nih.gov/pubmed/36075243
http://dx.doi.org/10.1016/S2213-2600(22)00261-2

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