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Stereoselective Domino Rearrangement peri-Annulation of Cinchona Alkaloid Derivatives with 8-Bromo-1-naphthyl Grignard
[Image: see text] The unexpected domino coupling and rearrangement of the Cinchona alkaloid skeleton has been found to occur in the reaction of 9-chloro-9-deoxy-alkaloids with Grignards from peri-dihalogenonaphthalene. The cyclization and migration of the central quinuclidinylmethyl group (C9) from...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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American Chemical Society
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9442652/ https://www.ncbi.nlm.nih.gov/pubmed/35998654 http://dx.doi.org/10.1021/acs.joc.2c01249 |