Stability of the gut microbiota in persons with paediatric-onset multiple sclerosis and related demyelinating diseases

OBJECTIVE: Examine if the gut microbiota composition changes across repeated samples in paediatric-onset multiple sclerosis (MS) or monophasic-acquired demyelinating syndromes (monoADS). METHODS: A total of 36 individuals (18 MS/18 monoADS) with ⩾2 stool samples were included. Stool sample-derived D...

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Detalles Bibliográficos
Autores principales: Liang, Geoffrey, Zhu, Feng, Mirza, Ali I, Bar-Or, Amit, Bernstein, Charles N, Bonner, Christine, Forbes, Jessica D, Graham, Morag, Hart, Janace, Knox, Natalie C, Marrie, Ruth Ann, O’Mahony, Julia, Van Domselaar, Gary, Yeh, E Ann, Zhao, Yinshan, Banwell, Brenda, Waubant, Emmanuelle, Tremlett, Helen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2022
Materias:
Short Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9442770/
https://www.ncbi.nlm.nih.gov/pubmed/35296164
http://dx.doi.org/10.1177/13524585221079533
Descripción
Sumario:OBJECTIVE: Examine if the gut microbiota composition changes across repeated samples in paediatric-onset multiple sclerosis (MS) or monophasic-acquired demyelinating syndromes (monoADS). METHODS: A total of 36 individuals (18 MS/18 monoADS) with ⩾2 stool samples were included. Stool sample-derived DNA was sequenced. Alpha/beta diversities and genus-level taxa were analysed. RESULTS: Mean ages at first sample procurement (MS/monoADS) = 18.0/13.8 years. Median time (months) between first/second samples = 11.2 and second/third = 10.3. Alpha/beta diversities did not differ between stool samples (p > 0.09), while one genus – Solobacterium did (p = 0.001). CONCLUSIONS: The gut microbiota composition in paediatric-onset MS and monoADS exhibited stability, suggesting that single stool sample procurement is a reasonable first approach.

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