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Stability of the gut microbiota in persons with paediatric-onset multiple sclerosis and related demyelinating diseases
OBJECTIVE: Examine if the gut microbiota composition changes across repeated samples in paediatric-onset multiple sclerosis (MS) or monophasic-acquired demyelinating syndromes (monoADS). METHODS: A total of 36 individuals (18 MS/18 monoADS) with ⩾2 stool samples were included. Stool sample-derived D...
| Autores principales: | , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
SAGE Publications
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9442770/ https://www.ncbi.nlm.nih.gov/pubmed/35296164 http://dx.doi.org/10.1177/13524585221079533 |
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| author | Liang, Geoffrey Zhu, Feng Mirza, Ali I Bar-Or, Amit Bernstein, Charles N Bonner, Christine Forbes, Jessica D Graham, Morag Hart, Janace Knox, Natalie C Marrie, Ruth Ann O’Mahony, Julia Van Domselaar, Gary Yeh, E Ann Zhao, Yinshan Banwell, Brenda Waubant, Emmanuelle Tremlett, Helen |
| author_facet | Liang, Geoffrey Zhu, Feng Mirza, Ali I Bar-Or, Amit Bernstein, Charles N Bonner, Christine Forbes, Jessica D Graham, Morag Hart, Janace Knox, Natalie C Marrie, Ruth Ann O’Mahony, Julia Van Domselaar, Gary Yeh, E Ann Zhao, Yinshan Banwell, Brenda Waubant, Emmanuelle Tremlett, Helen |
| author_sort | Liang, Geoffrey |
| collection | PubMed |
| description | OBJECTIVE: Examine if the gut microbiota composition changes across repeated samples in paediatric-onset multiple sclerosis (MS) or monophasic-acquired demyelinating syndromes (monoADS). METHODS: A total of 36 individuals (18 MS/18 monoADS) with ⩾2 stool samples were included. Stool sample-derived DNA was sequenced. Alpha/beta diversities and genus-level taxa were analysed. RESULTS: Mean ages at first sample procurement (MS/monoADS) = 18.0/13.8 years. Median time (months) between first/second samples = 11.2 and second/third = 10.3. Alpha/beta diversities did not differ between stool samples (p > 0.09), while one genus – Solobacterium did (p = 0.001). CONCLUSIONS: The gut microbiota composition in paediatric-onset MS and monoADS exhibited stability, suggesting that single stool sample procurement is a reasonable first approach. |
| format | Online Article Text |
| id | pubmed-9442770 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2022 |
| publisher | SAGE Publications |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-94427702022-09-06 Stability of the gut microbiota in persons with paediatric-onset multiple sclerosis and related demyelinating diseases Liang, Geoffrey Zhu, Feng Mirza, Ali I Bar-Or, Amit Bernstein, Charles N Bonner, Christine Forbes, Jessica D Graham, Morag Hart, Janace Knox, Natalie C Marrie, Ruth Ann O’Mahony, Julia Van Domselaar, Gary Yeh, E Ann Zhao, Yinshan Banwell, Brenda Waubant, Emmanuelle Tremlett, Helen Mult Scler Short Reports OBJECTIVE: Examine if the gut microbiota composition changes across repeated samples in paediatric-onset multiple sclerosis (MS) or monophasic-acquired demyelinating syndromes (monoADS). METHODS: A total of 36 individuals (18 MS/18 monoADS) with ⩾2 stool samples were included. Stool sample-derived DNA was sequenced. Alpha/beta diversities and genus-level taxa were analysed. RESULTS: Mean ages at first sample procurement (MS/monoADS) = 18.0/13.8 years. Median time (months) between first/second samples = 11.2 and second/third = 10.3. Alpha/beta diversities did not differ between stool samples (p > 0.09), while one genus – Solobacterium did (p = 0.001). CONCLUSIONS: The gut microbiota composition in paediatric-onset MS and monoADS exhibited stability, suggesting that single stool sample procurement is a reasonable first approach. SAGE Publications 2022-03-16 2022-10 /pmc/articles/PMC9442770/ /pubmed/35296164 http://dx.doi.org/10.1177/13524585221079533 Text en © The Author(s), 2022 https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution 4.0 License (https://creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
| spellingShingle | Short Reports Liang, Geoffrey Zhu, Feng Mirza, Ali I Bar-Or, Amit Bernstein, Charles N Bonner, Christine Forbes, Jessica D Graham, Morag Hart, Janace Knox, Natalie C Marrie, Ruth Ann O’Mahony, Julia Van Domselaar, Gary Yeh, E Ann Zhao, Yinshan Banwell, Brenda Waubant, Emmanuelle Tremlett, Helen Stability of the gut microbiota in persons with paediatric-onset multiple sclerosis and related demyelinating diseases |
| title | Stability of the gut microbiota in persons with paediatric-onset
multiple sclerosis and related demyelinating diseases |
| title_full | Stability of the gut microbiota in persons with paediatric-onset
multiple sclerosis and related demyelinating diseases |
| title_fullStr | Stability of the gut microbiota in persons with paediatric-onset
multiple sclerosis and related demyelinating diseases |
| title_full_unstemmed | Stability of the gut microbiota in persons with paediatric-onset
multiple sclerosis and related demyelinating diseases |
| title_short | Stability of the gut microbiota in persons with paediatric-onset
multiple sclerosis and related demyelinating diseases |
| title_sort | stability of the gut microbiota in persons with paediatric-onset
multiple sclerosis and related demyelinating diseases |
| topic | Short Reports |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9442770/ https://www.ncbi.nlm.nih.gov/pubmed/35296164 http://dx.doi.org/10.1177/13524585221079533 |
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