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The role of red cell distribution width in the locoregional recurrence of laryngeal cancer()
INTRODUCTION: Although the red cell distribution width has been reported as a reliable predictor of prognosis in several types of cancer, to our knowledge few reports have focused on the prognostic value of red cell distribution width in laryngeal carcinoma. OBJECTIVE: We aimed to explore whether th...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9442859/ https://www.ncbi.nlm.nih.gov/pubmed/29699878 http://dx.doi.org/10.1016/j.bjorl.2018.03.004 |
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author | Bozkurt, Gülpembe Korkut, Arzu Yasemin Soytaş, Pınar Dizdar, Senem Kurt Erol, Zeynep Nur |
author_facet | Bozkurt, Gülpembe Korkut, Arzu Yasemin Soytaş, Pınar Dizdar, Senem Kurt Erol, Zeynep Nur |
author_sort | Bozkurt, Gülpembe |
collection | PubMed |
description | INTRODUCTION: Although the red cell distribution width has been reported as a reliable predictor of prognosis in several types of cancer, to our knowledge few reports have focused on the prognostic value of red cell distribution width in laryngeal carcinoma. OBJECTIVE: We aimed to explore whether the pretreatment red cell distribution width predicted recurrence in laryngeal cancer patients is a simple, reproducible, and inexpensive prognostic biomarker. METHODS: All laryngeal cancer patients who underwent curative surgery (n = 132) over a 7 year study period were evaluated. Data on demographics, primary tumor site, T-stage, N-stage, histological features (differentiation; the presence of perineural/perivascular invasion), treatment group (total laryngectomy or partial laryngectomy) or adjuvant therapy (chemotherapy/radiotherapy); laboratory parameters (complete blood count, including the pre-operative red cell distribution width), and disease-free survival rates were retrospectively reviewed. All cases were divided into three groups by the red cell distribution width tertile [<13% (25th percentile) (n = 31), 13–14.4% (50th percentile) (n = 72), and >14.4% (75th percentile) (n = 29)]. RESULTS: High-red cell distribution width group included more patients of advanced age, and more of those with recurrent and metastatic tumors (p = 0.005, 0.048, and 0.043, respectively). Individuals with red cell distribution width >14.4% (75th percentile) had lower disease free survival rates than did those with red cell distribution width <13% (25th percentile) (p = 0.014). Patients with red cell distribution width >14.4% at diagnosis were at a higher risk of locoregional recurrence (hazard ratio = 5.818, 95% confidence interval (95% CI) 1.25–26.97; p = 0.024) than patients with a normal red cell distribution width (<13%). CONCLUSION: We found that the pretreatment red cell distribution width was independently prognostic of disease free survival rate in patients with laryngeal cancer and may serve as a new, accurate, and reproducible means of identifying early-stage laryngeal cancer patients with poorer prognoses. |
format | Online Article Text |
id | pubmed-9442859 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-94428592022-09-09 The role of red cell distribution width in the locoregional recurrence of laryngeal cancer() Bozkurt, Gülpembe Korkut, Arzu Yasemin Soytaş, Pınar Dizdar, Senem Kurt Erol, Zeynep Nur Braz J Otorhinolaryngol Original Article INTRODUCTION: Although the red cell distribution width has been reported as a reliable predictor of prognosis in several types of cancer, to our knowledge few reports have focused on the prognostic value of red cell distribution width in laryngeal carcinoma. OBJECTIVE: We aimed to explore whether the pretreatment red cell distribution width predicted recurrence in laryngeal cancer patients is a simple, reproducible, and inexpensive prognostic biomarker. METHODS: All laryngeal cancer patients who underwent curative surgery (n = 132) over a 7 year study period were evaluated. Data on demographics, primary tumor site, T-stage, N-stage, histological features (differentiation; the presence of perineural/perivascular invasion), treatment group (total laryngectomy or partial laryngectomy) or adjuvant therapy (chemotherapy/radiotherapy); laboratory parameters (complete blood count, including the pre-operative red cell distribution width), and disease-free survival rates were retrospectively reviewed. All cases were divided into three groups by the red cell distribution width tertile [<13% (25th percentile) (n = 31), 13–14.4% (50th percentile) (n = 72), and >14.4% (75th percentile) (n = 29)]. RESULTS: High-red cell distribution width group included more patients of advanced age, and more of those with recurrent and metastatic tumors (p = 0.005, 0.048, and 0.043, respectively). Individuals with red cell distribution width >14.4% (75th percentile) had lower disease free survival rates than did those with red cell distribution width <13% (25th percentile) (p = 0.014). Patients with red cell distribution width >14.4% at diagnosis were at a higher risk of locoregional recurrence (hazard ratio = 5.818, 95% confidence interval (95% CI) 1.25–26.97; p = 0.024) than patients with a normal red cell distribution width (<13%). CONCLUSION: We found that the pretreatment red cell distribution width was independently prognostic of disease free survival rate in patients with laryngeal cancer and may serve as a new, accurate, and reproducible means of identifying early-stage laryngeal cancer patients with poorer prognoses. Elsevier 2018-04-13 /pmc/articles/PMC9442859/ /pubmed/29699878 http://dx.doi.org/10.1016/j.bjorl.2018.03.004 Text en © 2018 Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial. Published by Elsevier Editora Ltda. https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Original Article Bozkurt, Gülpembe Korkut, Arzu Yasemin Soytaş, Pınar Dizdar, Senem Kurt Erol, Zeynep Nur The role of red cell distribution width in the locoregional recurrence of laryngeal cancer() |
title | The role of red cell distribution width in the locoregional recurrence of laryngeal cancer() |
title_full | The role of red cell distribution width in the locoregional recurrence of laryngeal cancer() |
title_fullStr | The role of red cell distribution width in the locoregional recurrence of laryngeal cancer() |
title_full_unstemmed | The role of red cell distribution width in the locoregional recurrence of laryngeal cancer() |
title_short | The role of red cell distribution width in the locoregional recurrence of laryngeal cancer() |
title_sort | role of red cell distribution width in the locoregional recurrence of laryngeal cancer() |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9442859/ https://www.ncbi.nlm.nih.gov/pubmed/29699878 http://dx.doi.org/10.1016/j.bjorl.2018.03.004 |
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