Alterations of functional connectivity of the lateral habenula in subclinical depression and major depressive disorder

BACKGROUND: Major depressive disorder (MDD) is a common cause of disability and morbidity, affecting about 10% of the population worldwide. Subclinical depression (SD) can be understood as a precursor of MDD, and therefore provides an MDD risk indicator. The pathogenesis of MDD and SD in humans is s...

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Autores principales: Yang, Lei, Jin, Chaoyang, Qi, Shouliang, Teng, Yueyang, Li, Chen, Yao, Yudong, Ruan, Xiuhang, Wei, Xinhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9442927/
https://www.ncbi.nlm.nih.gov/pubmed/36064380
http://dx.doi.org/10.1186/s12888-022-04221-6
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author Yang, Lei
Jin, Chaoyang
Qi, Shouliang
Teng, Yueyang
Li, Chen
Yao, Yudong
Ruan, Xiuhang
Wei, Xinhua
author_facet Yang, Lei
Jin, Chaoyang
Qi, Shouliang
Teng, Yueyang
Li, Chen
Yao, Yudong
Ruan, Xiuhang
Wei, Xinhua
author_sort Yang, Lei
collection PubMed
description BACKGROUND: Major depressive disorder (MDD) is a common cause of disability and morbidity, affecting about 10% of the population worldwide. Subclinical depression (SD) can be understood as a precursor of MDD, and therefore provides an MDD risk indicator. The pathogenesis of MDD and SD in humans is still unclear, and the current diagnosis lacks accurate biomarkers and gold standards. METHODS: A total of 40 MDD, 34 SD, and 40 healthy control (HC) participants matched by age, gender, and education were included in this study. Resting-state functional magnetic resonance images (rs-fMRI) were used to analyze the functional connectivity (FC) of the posterior parietal thalamus (PPtha), which includes the lateral habenula, as the region of interest. Analysis of variance with the post hoc t-test test was performed to find significant differences in FC and clarify the variations in FC among the HC, SD, and MDD groups. RESULTS: Increased FC was observed between PPtha and the left inferior temporal gyrus (ITG) for MDD versus SD, and between PPtha and the right ITG for SD versus HC. Conversely, decreased FC was observed between PPtha and the right middle temporal gyrus (MTG) for MDD versus SD and MDD versus HC. The FC between PPtha and the middle frontal gyrus (MFG) in SD was higher than that in MDD and HC. Compared with the HC group, the FC of PPtha-ITG (left and right) increased in both the SD and MDD groups, PPtha-MTG (right) decreased in both the SD and MDD groups and PPtha-MFG (right) increased in the SD group and decreased in the MDD group. CONCLUSION: Through analysis of FC measured by rs-fMRI, the altered FC between PPtha and several brain regions (right and left ITG, right MTG, and right MFG) has been identified in participants with SD and MDD. Different alterations in FC between PPtha and these regions were identified for patients with depression. These findings might provide insights into the potential pathophysiological mechanisms of SD and MDD, especially related to PPtha and the lateral habenula.
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spelling pubmed-94429272022-09-06 Alterations of functional connectivity of the lateral habenula in subclinical depression and major depressive disorder Yang, Lei Jin, Chaoyang Qi, Shouliang Teng, Yueyang Li, Chen Yao, Yudong Ruan, Xiuhang Wei, Xinhua BMC Psychiatry Research BACKGROUND: Major depressive disorder (MDD) is a common cause of disability and morbidity, affecting about 10% of the population worldwide. Subclinical depression (SD) can be understood as a precursor of MDD, and therefore provides an MDD risk indicator. The pathogenesis of MDD and SD in humans is still unclear, and the current diagnosis lacks accurate biomarkers and gold standards. METHODS: A total of 40 MDD, 34 SD, and 40 healthy control (HC) participants matched by age, gender, and education were included in this study. Resting-state functional magnetic resonance images (rs-fMRI) were used to analyze the functional connectivity (FC) of the posterior parietal thalamus (PPtha), which includes the lateral habenula, as the region of interest. Analysis of variance with the post hoc t-test test was performed to find significant differences in FC and clarify the variations in FC among the HC, SD, and MDD groups. RESULTS: Increased FC was observed between PPtha and the left inferior temporal gyrus (ITG) for MDD versus SD, and between PPtha and the right ITG for SD versus HC. Conversely, decreased FC was observed between PPtha and the right middle temporal gyrus (MTG) for MDD versus SD and MDD versus HC. The FC between PPtha and the middle frontal gyrus (MFG) in SD was higher than that in MDD and HC. Compared with the HC group, the FC of PPtha-ITG (left and right) increased in both the SD and MDD groups, PPtha-MTG (right) decreased in both the SD and MDD groups and PPtha-MFG (right) increased in the SD group and decreased in the MDD group. CONCLUSION: Through analysis of FC measured by rs-fMRI, the altered FC between PPtha and several brain regions (right and left ITG, right MTG, and right MFG) has been identified in participants with SD and MDD. Different alterations in FC between PPtha and these regions were identified for patients with depression. These findings might provide insights into the potential pathophysiological mechanisms of SD and MDD, especially related to PPtha and the lateral habenula. BioMed Central 2022-09-05 /pmc/articles/PMC9442927/ /pubmed/36064380 http://dx.doi.org/10.1186/s12888-022-04221-6 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Yang, Lei
Jin, Chaoyang
Qi, Shouliang
Teng, Yueyang
Li, Chen
Yao, Yudong
Ruan, Xiuhang
Wei, Xinhua
Alterations of functional connectivity of the lateral habenula in subclinical depression and major depressive disorder
title Alterations of functional connectivity of the lateral habenula in subclinical depression and major depressive disorder
title_full Alterations of functional connectivity of the lateral habenula in subclinical depression and major depressive disorder
title_fullStr Alterations of functional connectivity of the lateral habenula in subclinical depression and major depressive disorder
title_full_unstemmed Alterations of functional connectivity of the lateral habenula in subclinical depression and major depressive disorder
title_short Alterations of functional connectivity of the lateral habenula in subclinical depression and major depressive disorder
title_sort alterations of functional connectivity of the lateral habenula in subclinical depression and major depressive disorder
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9442927/
https://www.ncbi.nlm.nih.gov/pubmed/36064380
http://dx.doi.org/10.1186/s12888-022-04221-6
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