Occult infection with hepatitis B virus PreS variants synergistically promotes hepatocellular carcinoma development in a high-fat diet context by generating abnormal ceramides

BACKGROUND: Some occult hepatitis B virus (HBV) infections are resulted from PreS mutations that reduce secretion of envelope protein (HBsAg). We investigated the ceramide amounts and species in hepatocytes infected with PreS variants that were isolated from HBsAg-seronegative patients with hepatoce...

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Detalles Bibliográficos
Autores principales: Liu, Chang, Chen, Kun, Zhao, Fei, Xuan, Lingling, Wang, Yuting, Xu, Chungui, Wu, Zhiyuan, Wang, Dongmei, Qu, Chunfeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9442965/
https://www.ncbi.nlm.nih.gov/pubmed/36058909
http://dx.doi.org/10.1186/s12916-022-02481-3

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