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Factors secreted by monosodium urate crystal-stimulated macrophages promote a proinflammatory state in osteoblasts: a potential indirect mechanism of bone erosion in gout

BACKGROUND: Tophi are lesions commonly present at sites of bone erosion in gout-affected joints. The tophus comprises a core of monosodium urate (MSU) crystals surrounded by soft tissue that contains macrophages and other immune cells. Previous studies found that MSU crystals directly reduce osteobl...

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Detalles Bibliográficos
Autores principales:	Naot, Dorit, Pool, Bregina, Chhana, Ashika, Gao, Ryan, Munro, Jacob T., Cornish, Jillian, Dalbeth, Nicola
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9442999/ https://www.ncbi.nlm.nih.gov/pubmed/36064735 http://dx.doi.org/10.1186/s13075-022-02900-z

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