Electrogenerated base-promoted cyclopropanation using alkyl 2-chloroacetates

The electrochemical reduction conditions of the reaction of alkyl 2-chloroacetates in Bu(4)NBr/DMF using a divided cell equipped with Pt electrodes to produce the corresponding cyclopropane derivatives in moderate yields were discovered. The reaction conditions were optimized, the scope and limitati...

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Detalles Bibliográficos
Autores principales: Matsumoto, Kouichi, Hayashi, Yuta, Hamasaki, Kengo, Matsuse, Mizuki, Suzuki, Hiyono, Nishiwaki, Keiji, Kawashita, Norihito
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2022
Materias:
Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9443391/
https://www.ncbi.nlm.nih.gov/pubmed/36105721
http://dx.doi.org/10.3762/bjoc.18.114
Descripción
Sumario:The electrochemical reduction conditions of the reaction of alkyl 2-chloroacetates in Bu(4)NBr/DMF using a divided cell equipped with Pt electrodes to produce the corresponding cyclopropane derivatives in moderate yields were discovered. The reaction conditions were optimized, the scope and limitations, as well as scale-up reactions were investigated. The presented method for the electrochemical production of cyclopropane derivatives is an environmentally friendly and easy to perform synthetic procedure.

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