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Facile and diastereoselective arylation of the privileged 1,4-dihydroisoquinolin-3(2H)-one scaffold

A practically convenient and streamlined protocol for the trans-diastereoselective introduction of an aryl substituent at position 4 of the 1,4-dihydroisoquinol-3-one (1,4-DHIQ) scaffold is presented. The protocol involves direct Regitz diazo transfer onto readily available 3(2H)-isoquinolones follo...

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Detalles Bibliográficos
Autores principales:	Dar’in, Dmitry, Kantin, Grigory, Bunev, Alexander, Krasavin, Mikhail
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Beilstein-Institut 2022
Materias:	Letter
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9443417/ https://www.ncbi.nlm.nih.gov/pubmed/36105725 http://dx.doi.org/10.3762/bjoc.18.109

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