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FOXM1 is regulated by DEPDC1 to facilitate development and metastasis of oral squamous cell carcinoma
The Disheveled, EGL-10, Pleckstrin domain containing 1 (DEPDC1) is a new oncogene that has recently been described. The mechanisms and functions of its expression are yet to be determined in oral squamous cell carcinoma (OSCC). In the present study, the impact of DEPDC1 on the growth and development...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9443502/ https://www.ncbi.nlm.nih.gov/pubmed/36072787 http://dx.doi.org/10.3389/fonc.2022.815998 |
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author | Qiu, Jing Tang, Yongping Liu, Lan Yu, Jiangbo Chen, Zhenggang Chen, Hao Yuan, Rongtao |
author_facet | Qiu, Jing Tang, Yongping Liu, Lan Yu, Jiangbo Chen, Zhenggang Chen, Hao Yuan, Rongtao |
author_sort | Qiu, Jing |
collection | PubMed |
description | The Disheveled, EGL-10, Pleckstrin domain containing 1 (DEPDC1) is a new oncogene that has recently been described. The mechanisms and functions of its expression are yet to be determined in oral squamous cell carcinoma (OSCC). In the present study, the impact of DEPDC1 on the growth and development of OSCC was investigated using animal models, cell lines and human tissue samples. Elevated DEPDC1 expression within cancer cell lines and human OSCC has been identified. Mechanistic examination showed that restored DEPDC1 expression in vivo and in vitro stimulated OSCC tumour development. In addition, FOXM1 interacts with DEPDC1 as indicated by co-immunoprecipitation and immunofluorescence testing. Functionally, DEPDC1 facilitated Wnt/β-catenin signal transduction and β-catenin protein nuclear expression. In summary, the DEPDC1, interacting with FOXM1 via Wnt/β-catenin signaling, the closely regulated OSCC pathogenesis, suggesting that targeting the novel DEPDC1/FOXM1/β-catenin complex is an essential OSCC therapeutic approach. |
format | Online Article Text |
id | pubmed-9443502 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-94435022022-09-06 FOXM1 is regulated by DEPDC1 to facilitate development and metastasis of oral squamous cell carcinoma Qiu, Jing Tang, Yongping Liu, Lan Yu, Jiangbo Chen, Zhenggang Chen, Hao Yuan, Rongtao Front Oncol Oncology The Disheveled, EGL-10, Pleckstrin domain containing 1 (DEPDC1) is a new oncogene that has recently been described. The mechanisms and functions of its expression are yet to be determined in oral squamous cell carcinoma (OSCC). In the present study, the impact of DEPDC1 on the growth and development of OSCC was investigated using animal models, cell lines and human tissue samples. Elevated DEPDC1 expression within cancer cell lines and human OSCC has been identified. Mechanistic examination showed that restored DEPDC1 expression in vivo and in vitro stimulated OSCC tumour development. In addition, FOXM1 interacts with DEPDC1 as indicated by co-immunoprecipitation and immunofluorescence testing. Functionally, DEPDC1 facilitated Wnt/β-catenin signal transduction and β-catenin protein nuclear expression. In summary, the DEPDC1, interacting with FOXM1 via Wnt/β-catenin signaling, the closely regulated OSCC pathogenesis, suggesting that targeting the novel DEPDC1/FOXM1/β-catenin complex is an essential OSCC therapeutic approach. Frontiers Media S.A. 2022-08-22 /pmc/articles/PMC9443502/ /pubmed/36072787 http://dx.doi.org/10.3389/fonc.2022.815998 Text en Copyright © 2022 Qiu, Tang, Liu, Yu, Chen, Chen and Yuan https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Qiu, Jing Tang, Yongping Liu, Lan Yu, Jiangbo Chen, Zhenggang Chen, Hao Yuan, Rongtao FOXM1 is regulated by DEPDC1 to facilitate development and metastasis of oral squamous cell carcinoma |
title | FOXM1 is regulated by DEPDC1 to facilitate development and metastasis of oral squamous cell carcinoma |
title_full | FOXM1 is regulated by DEPDC1 to facilitate development and metastasis of oral squamous cell carcinoma |
title_fullStr | FOXM1 is regulated by DEPDC1 to facilitate development and metastasis of oral squamous cell carcinoma |
title_full_unstemmed | FOXM1 is regulated by DEPDC1 to facilitate development and metastasis of oral squamous cell carcinoma |
title_short | FOXM1 is regulated by DEPDC1 to facilitate development and metastasis of oral squamous cell carcinoma |
title_sort | foxm1 is regulated by depdc1 to facilitate development and metastasis of oral squamous cell carcinoma |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9443502/ https://www.ncbi.nlm.nih.gov/pubmed/36072787 http://dx.doi.org/10.3389/fonc.2022.815998 |
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