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Lymph node reactivity and microvessel density in neck metastases of unknown primary squamous cell carcinoma

BACKGROUND: neoangiogenesis and the immune response are important mechanisms in metastasis development. AIM: to evaluate lymph node reactivity and microvessel density in neck metastasis of occult primary squamous cell carcinoma considering their histological and clinical variables. STUDY DESIGN: ret...

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Autores principales: Amar, Ali, Giovanini, Allan Fernando, Rosas, Marilene Paladino, Cervantes, Onivaldo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9443603/
https://www.ncbi.nlm.nih.gov/pubmed/17119776
http://dx.doi.org/10.1016/S1808-8694(15)30973-3
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author Amar, Ali
Giovanini, Allan Fernando
Rosas, Marilene Paladino
Cervantes, Onivaldo
author_facet Amar, Ali
Giovanini, Allan Fernando
Rosas, Marilene Paladino
Cervantes, Onivaldo
author_sort Amar, Ali
collection PubMed
description BACKGROUND: neoangiogenesis and the immune response are important mechanisms in metastasis development. AIM: to evaluate lymph node reactivity and microvessel density in neck metastasis of occult primary squamous cell carcinoma considering their histological and clinical variables. STUDY DESIGN: retrospesctive case-series. METHOD: 19 patients with neck metastasis of occult primary squamous cell carcinoma who underwent neck dissection between 1983 and 2000 were selected. The lymph nodes were reevaluated on the type of reactivity in both the cortical and paracortical areas, and the metastasis were assessed as to grade, desmoplasia, necrosis and microvessel density (CD34). The relationship between histological and clinical variables was evaluated. RESULTS: the median microvessel density was 91 vessels/mm2, varying from 28 to 145. Paracortical hyperplasia was more common in patients below 55 years of age (90% x 44%, p=0.05), but there was no relationship between reactivity patterns and microvessel density with prognosis. The disease-free survival was 52% in 3 years, being similar in both groups, with higher or lower microvessel densities. CONCLUSION: microvessel density in neck metastasis of occult primary squamous cell carcinoma had a great individual variability. It wasn't possible to establish the relationship between microvessel density and the clinical or histological variables studied.
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spelling pubmed-94436032022-09-09 Lymph node reactivity and microvessel density in neck metastases of unknown primary squamous cell carcinoma Amar, Ali Giovanini, Allan Fernando Rosas, Marilene Paladino Cervantes, Onivaldo Braz J Otorhinolaryngol Original Article BACKGROUND: neoangiogenesis and the immune response are important mechanisms in metastasis development. AIM: to evaluate lymph node reactivity and microvessel density in neck metastasis of occult primary squamous cell carcinoma considering their histological and clinical variables. STUDY DESIGN: retrospesctive case-series. METHOD: 19 patients with neck metastasis of occult primary squamous cell carcinoma who underwent neck dissection between 1983 and 2000 were selected. The lymph nodes were reevaluated on the type of reactivity in both the cortical and paracortical areas, and the metastasis were assessed as to grade, desmoplasia, necrosis and microvessel density (CD34). The relationship between histological and clinical variables was evaluated. RESULTS: the median microvessel density was 91 vessels/mm2, varying from 28 to 145. Paracortical hyperplasia was more common in patients below 55 years of age (90% x 44%, p=0.05), but there was no relationship between reactivity patterns and microvessel density with prognosis. The disease-free survival was 52% in 3 years, being similar in both groups, with higher or lower microvessel densities. CONCLUSION: microvessel density in neck metastasis of occult primary squamous cell carcinoma had a great individual variability. It wasn't possible to establish the relationship between microvessel density and the clinical or histological variables studied. Elsevier 2015-10-19 /pmc/articles/PMC9443603/ /pubmed/17119776 http://dx.doi.org/10.1016/S1808-8694(15)30973-3 Text en . https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Original Article
Amar, Ali
Giovanini, Allan Fernando
Rosas, Marilene Paladino
Cervantes, Onivaldo
Lymph node reactivity and microvessel density in neck metastases of unknown primary squamous cell carcinoma
title Lymph node reactivity and microvessel density in neck metastases of unknown primary squamous cell carcinoma
title_full Lymph node reactivity and microvessel density in neck metastases of unknown primary squamous cell carcinoma
title_fullStr Lymph node reactivity and microvessel density in neck metastases of unknown primary squamous cell carcinoma
title_full_unstemmed Lymph node reactivity and microvessel density in neck metastases of unknown primary squamous cell carcinoma
title_short Lymph node reactivity and microvessel density in neck metastases of unknown primary squamous cell carcinoma
title_sort lymph node reactivity and microvessel density in neck metastases of unknown primary squamous cell carcinoma
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9443603/
https://www.ncbi.nlm.nih.gov/pubmed/17119776
http://dx.doi.org/10.1016/S1808-8694(15)30973-3
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