Monkeypox: disease epidemiology, host immunity and clinical interventions

Monkeypox virus (MPXV), which causes disease in humans, has for many years been restricted to the African continent, with only a handful of sporadic cases in other parts of the world. However, unprecedented outbreaks of monkeypox in non-endemic regions have recently taken the world by surprise. In l...

Descripción completa

Detalles Bibliográficos
Autores principales: Lum, Fok-Moon, Torres-Ruesta, Anthony, Tay, Matthew Z., Lin, Raymond T. P., Lye, David C., Rénia, Laurent, Ng, Lisa F. P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9443635/
https://www.ncbi.nlm.nih.gov/pubmed/36064780
http://dx.doi.org/10.1038/s41577-022-00775-4
_version_ 1784783029639577600
author Lum, Fok-Moon
Torres-Ruesta, Anthony
Tay, Matthew Z.
Lin, Raymond T. P.
Lye, David C.
Rénia, Laurent
Ng, Lisa F. P.
author_facet Lum, Fok-Moon
Torres-Ruesta, Anthony
Tay, Matthew Z.
Lin, Raymond T. P.
Lye, David C.
Rénia, Laurent
Ng, Lisa F. P.
author_sort Lum, Fok-Moon
collection PubMed
description Monkeypox virus (MPXV), which causes disease in humans, has for many years been restricted to the African continent, with only a handful of sporadic cases in other parts of the world. However, unprecedented outbreaks of monkeypox in non-endemic regions have recently taken the world by surprise. In less than 4 months, the number of detected MPXV infections has soared to more than 48,000 cases, recording a total of 13 deaths. In this Review, we discuss the clinical, epidemiological and immunological features of MPXV infections. We also highlight important research questions and new opportunities to tackle the ongoing monkeypox outbreak.
format Online
Article
Text
id pubmed-9443635
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-94436352022-09-06 Monkeypox: disease epidemiology, host immunity and clinical interventions Lum, Fok-Moon Torres-Ruesta, Anthony Tay, Matthew Z. Lin, Raymond T. P. Lye, David C. Rénia, Laurent Ng, Lisa F. P. Nat Rev Immunol Review Article Monkeypox virus (MPXV), which causes disease in humans, has for many years been restricted to the African continent, with only a handful of sporadic cases in other parts of the world. However, unprecedented outbreaks of monkeypox in non-endemic regions have recently taken the world by surprise. In less than 4 months, the number of detected MPXV infections has soared to more than 48,000 cases, recording a total of 13 deaths. In this Review, we discuss the clinical, epidemiological and immunological features of MPXV infections. We also highlight important research questions and new opportunities to tackle the ongoing monkeypox outbreak. Nature Publishing Group UK 2022-09-05 2022 /pmc/articles/PMC9443635/ /pubmed/36064780 http://dx.doi.org/10.1038/s41577-022-00775-4 Text en © Springer Nature Limited 2022, Springer Nature or its licensor holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Review Article
Lum, Fok-Moon
Torres-Ruesta, Anthony
Tay, Matthew Z.
Lin, Raymond T. P.
Lye, David C.
Rénia, Laurent
Ng, Lisa F. P.
Monkeypox: disease epidemiology, host immunity and clinical interventions
title Monkeypox: disease epidemiology, host immunity and clinical interventions
title_full Monkeypox: disease epidemiology, host immunity and clinical interventions
title_fullStr Monkeypox: disease epidemiology, host immunity and clinical interventions
title_full_unstemmed Monkeypox: disease epidemiology, host immunity and clinical interventions
title_short Monkeypox: disease epidemiology, host immunity and clinical interventions
title_sort monkeypox: disease epidemiology, host immunity and clinical interventions
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9443635/
https://www.ncbi.nlm.nih.gov/pubmed/36064780
http://dx.doi.org/10.1038/s41577-022-00775-4
work_keys_str_mv AT lumfokmoon monkeypoxdiseaseepidemiologyhostimmunityandclinicalinterventions
AT torresruestaanthony monkeypoxdiseaseepidemiologyhostimmunityandclinicalinterventions
AT taymatthewz monkeypoxdiseaseepidemiologyhostimmunityandclinicalinterventions
AT linraymondtp monkeypoxdiseaseepidemiologyhostimmunityandclinicalinterventions
AT lyedavidc monkeypoxdiseaseepidemiologyhostimmunityandclinicalinterventions
AT renialaurent monkeypoxdiseaseepidemiologyhostimmunityandclinicalinterventions
AT nglisafp monkeypoxdiseaseepidemiologyhostimmunityandclinicalinterventions

Ejemplares similares