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Effect of green propolis on oral epithelial dysplasia in rats
Studies have demonstrated that flavonoid compounds of green propolis have antitumoral activity. Study Design: Experimental study. AIMS: To evaluate the effect of a hydroalcoholic extract of green propolis (EPV) on chemically induced epithelial dysplasias in rat tongues. METHODS AND MATERIALS: DMBA w...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Elsevier
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9443718/ https://www.ncbi.nlm.nih.gov/pubmed/21738999 http://dx.doi.org/10.1590/S1808-86942011000300002 |
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author | Cavalcante, Danielle Rodrigues Ribeiro de Oliveira, Paula Santos Góis, Sandro Mota Soares, Andréa Ferreira Cardoso, Juliana Cordeiro Padilha, Francine Ferreira de Albuquerque Júnior, Ricardo Luiz Cavalcanti |
author_facet | Cavalcante, Danielle Rodrigues Ribeiro de Oliveira, Paula Santos Góis, Sandro Mota Soares, Andréa Ferreira Cardoso, Juliana Cordeiro Padilha, Francine Ferreira de Albuquerque Júnior, Ricardo Luiz Cavalcanti |
author_sort | Cavalcante, Danielle Rodrigues Ribeiro |
collection | PubMed |
description | Studies have demonstrated that flavonoid compounds of green propolis have antitumoral activity. Study Design: Experimental study. AIMS: To evaluate the effect of a hydroalcoholic extract of green propolis (EPV) on chemically induced epithelial dysplasias in rat tongues. METHODS AND MATERIALS: DMBA was brushed on the lingual dorsum of rats 3x/week on alternate days - 100 (PROP1), 200 (PROP2) and 300 mg/kg (PROP3) EPV was administered orally for 20 weeks. EPV or DMBA were replaced by their vehicles and applied as positive (TUM1 and TUM2) and negative controls (CTR1 and CTR2), respectively. The lingual epithelium was histologically analyzed and graded according a binary system and the WHO classification; the data were compared using ANOVA (*p<0.05). RESULTS: The EPV yield was 41% and the flavonoid yield was 0.95±0.44%. According to the Binary System, TUM1, TUM2 and PROP1 were considered high risk lesions, with significantly higher morphological alteration rates compared to the other groups (p<0.05), which were considered low risk lesions. Based on the WHO classification, moderate dysplasia was TUM1 and TUM2, mild dysplasia was PROP1, PROP2 and PROP3, and non-dysplastic epithelium was CTR1 and CTR2. CONCLUSION: EPV seems to play an important protective role against chemically-induced lingual carcinogenesis in rats. |
format | Online Article Text |
id | pubmed-9443718 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-94437182022-09-09 Effect of green propolis on oral epithelial dysplasia in rats Cavalcante, Danielle Rodrigues Ribeiro de Oliveira, Paula Santos Góis, Sandro Mota Soares, Andréa Ferreira Cardoso, Juliana Cordeiro Padilha, Francine Ferreira de Albuquerque Júnior, Ricardo Luiz Cavalcanti Braz J Otorhinolaryngol Original Article Studies have demonstrated that flavonoid compounds of green propolis have antitumoral activity. Study Design: Experimental study. AIMS: To evaluate the effect of a hydroalcoholic extract of green propolis (EPV) on chemically induced epithelial dysplasias in rat tongues. METHODS AND MATERIALS: DMBA was brushed on the lingual dorsum of rats 3x/week on alternate days - 100 (PROP1), 200 (PROP2) and 300 mg/kg (PROP3) EPV was administered orally for 20 weeks. EPV or DMBA were replaced by their vehicles and applied as positive (TUM1 and TUM2) and negative controls (CTR1 and CTR2), respectively. The lingual epithelium was histologically analyzed and graded according a binary system and the WHO classification; the data were compared using ANOVA (*p<0.05). RESULTS: The EPV yield was 41% and the flavonoid yield was 0.95±0.44%. According to the Binary System, TUM1, TUM2 and PROP1 were considered high risk lesions, with significantly higher morphological alteration rates compared to the other groups (p<0.05), which were considered low risk lesions. Based on the WHO classification, moderate dysplasia was TUM1 and TUM2, mild dysplasia was PROP1, PROP2 and PROP3, and non-dysplastic epithelium was CTR1 and CTR2. CONCLUSION: EPV seems to play an important protective role against chemically-induced lingual carcinogenesis in rats. Elsevier 2015-10-19 /pmc/articles/PMC9443718/ /pubmed/21738999 http://dx.doi.org/10.1590/S1808-86942011000300002 Text en . https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Original Article Cavalcante, Danielle Rodrigues Ribeiro de Oliveira, Paula Santos Góis, Sandro Mota Soares, Andréa Ferreira Cardoso, Juliana Cordeiro Padilha, Francine Ferreira de Albuquerque Júnior, Ricardo Luiz Cavalcanti Effect of green propolis on oral epithelial dysplasia in rats |
title | Effect of green propolis on oral epithelial dysplasia in rats |
title_full | Effect of green propolis on oral epithelial dysplasia in rats |
title_fullStr | Effect of green propolis on oral epithelial dysplasia in rats |
title_full_unstemmed | Effect of green propolis on oral epithelial dysplasia in rats |
title_short | Effect of green propolis on oral epithelial dysplasia in rats |
title_sort | effect of green propolis on oral epithelial dysplasia in rats |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9443718/ https://www.ncbi.nlm.nih.gov/pubmed/21738999 http://dx.doi.org/10.1590/S1808-86942011000300002 |
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