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Polymorphism of Methylenetetrahydrofolate Reductase (MTHFR) gene and risk of Head and Neck Squamous Cell Carcinoma
ABSTRACT: Methylenetetrahydrofolate reductase gene (MTHFR) C677T polymorphism may be a risk factor for head and neck squamous cell carcinoma due to changes in folate levels that can induce disorders in the methylation pathway, which results in carcinogenesis. AIM: To evaluate MTHFR C677T polymorphis...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Elsevier
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9443740/ https://www.ncbi.nlm.nih.gov/pubmed/21180947 http://dx.doi.org/10.1590/S1808-86942010000600017 |
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author | Rodrigues, Juliana Olsen Galbiatti, Ana Lívia Silva Ruiz, Mariangela Torreglosa Raposo, Luiz Sergio Maniglia, José Victor Pavarino-Bertelli, Érika Cristina Goloni-Bertollo, Eny Maria |
author_facet | Rodrigues, Juliana Olsen Galbiatti, Ana Lívia Silva Ruiz, Mariangela Torreglosa Raposo, Luiz Sergio Maniglia, José Victor Pavarino-Bertelli, Érika Cristina Goloni-Bertollo, Eny Maria |
author_sort | Rodrigues, Juliana Olsen |
collection | PubMed |
description | ABSTRACT: Methylenetetrahydrofolate reductase gene (MTHFR) C677T polymorphism may be a risk factor for head and neck squamous cell carcinoma due to changes in folate levels that can induce disorders in the methylation pathway, which results in carcinogenesis. AIM: To evaluate MTHFR C677T polymorphism in patients with head and neck squamous cell carcinoma and in individuals with no history of cancer, and to assess the association of this disease with clinical histopathological parameters. SERIES AND METHODS: A retrospective study that assessed gender, age, tobacco, alcohol consumption and clinical histopathological parameters in 200 patients (100 with disease and 100 with no history of cancer). PCR-RFLP molecular analysis was carried out and the chi-square test and multiple logistic regression were applied for the statistical analysis. RESULTS: There was no association between MTHFR C677T polymorphism and head and neck cancer (p = 0.50). Significant differences between the study and control groups were observed at age over 50 years, tobacco use, and male gender (p <0.001). There was no association of disease with clinical-histopathological parameters. CONCLUSION: No association between the MTHFR C677T polymorphism and head and neck squamous cell carcinoma was possible in this study. |
format | Online Article Text |
id | pubmed-9443740 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-94437402022-09-09 Polymorphism of Methylenetetrahydrofolate Reductase (MTHFR) gene and risk of Head and Neck Squamous Cell Carcinoma Rodrigues, Juliana Olsen Galbiatti, Ana Lívia Silva Ruiz, Mariangela Torreglosa Raposo, Luiz Sergio Maniglia, José Victor Pavarino-Bertelli, Érika Cristina Goloni-Bertollo, Eny Maria Braz J Otorhinolaryngol Original Article ABSTRACT: Methylenetetrahydrofolate reductase gene (MTHFR) C677T polymorphism may be a risk factor for head and neck squamous cell carcinoma due to changes in folate levels that can induce disorders in the methylation pathway, which results in carcinogenesis. AIM: To evaluate MTHFR C677T polymorphism in patients with head and neck squamous cell carcinoma and in individuals with no history of cancer, and to assess the association of this disease with clinical histopathological parameters. SERIES AND METHODS: A retrospective study that assessed gender, age, tobacco, alcohol consumption and clinical histopathological parameters in 200 patients (100 with disease and 100 with no history of cancer). PCR-RFLP molecular analysis was carried out and the chi-square test and multiple logistic regression were applied for the statistical analysis. RESULTS: There was no association between MTHFR C677T polymorphism and head and neck cancer (p = 0.50). Significant differences between the study and control groups were observed at age over 50 years, tobacco use, and male gender (p <0.001). There was no association of disease with clinical-histopathological parameters. CONCLUSION: No association between the MTHFR C677T polymorphism and head and neck squamous cell carcinoma was possible in this study. Elsevier 2015-10-19 /pmc/articles/PMC9443740/ /pubmed/21180947 http://dx.doi.org/10.1590/S1808-86942010000600017 Text en . https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Original Article Rodrigues, Juliana Olsen Galbiatti, Ana Lívia Silva Ruiz, Mariangela Torreglosa Raposo, Luiz Sergio Maniglia, José Victor Pavarino-Bertelli, Érika Cristina Goloni-Bertollo, Eny Maria Polymorphism of Methylenetetrahydrofolate Reductase (MTHFR) gene and risk of Head and Neck Squamous Cell Carcinoma |
title | Polymorphism of Methylenetetrahydrofolate Reductase (MTHFR) gene and risk of Head and Neck Squamous Cell Carcinoma |
title_full | Polymorphism of Methylenetetrahydrofolate Reductase (MTHFR) gene and risk of Head and Neck Squamous Cell Carcinoma |
title_fullStr | Polymorphism of Methylenetetrahydrofolate Reductase (MTHFR) gene and risk of Head and Neck Squamous Cell Carcinoma |
title_full_unstemmed | Polymorphism of Methylenetetrahydrofolate Reductase (MTHFR) gene and risk of Head and Neck Squamous Cell Carcinoma |
title_short | Polymorphism of Methylenetetrahydrofolate Reductase (MTHFR) gene and risk of Head and Neck Squamous Cell Carcinoma |
title_sort | polymorphism of methylenetetrahydrofolate reductase (mthfr) gene and risk of head and neck squamous cell carcinoma |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9443740/ https://www.ncbi.nlm.nih.gov/pubmed/21180947 http://dx.doi.org/10.1590/S1808-86942010000600017 |
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