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Enhancing neuroimaging genetics through meta-analysis for Tourette syndrome (ENIGMA-TS): A worldwide platform for collaboration

Tourette syndrome (TS) is characterized by multiple motor and vocal tics, and high-comorbidity rates with other neuropsychiatric disorders. Obsessive compulsive disorder (OCD), attention deficit hyperactivity disorder (ADHD), autism spectrum disorders (ASDs), major depressive disorder (MDD), and anx...

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Autores principales: Paschou, Peristera, Jin, Yin, Müller-Vahl, Kirsten, Möller, Harald E., Rizzo, Renata, Hoekstra, Pieter J., Roessner, Veit, Mol Debes, Nanette, Worbe, Yulia, Hartmann, Andreas, Mir, Pablo, Cath, Danielle, Neuner, Irene, Eichele, Heike, Zhang, Chencheng, Lewandowska, Katarzyna, Munchau, Alexander, Verrel, Julius, Musil, Richard, Silk, Tim J., Hanlon, Colleen A., Bihun, Emily D., Brandt, Valerie, Dietrich, Andrea, Forde, Natalie, Ganos, Christos, Greene, Deanna J., Chu, Chunguang, Grothe, Michel J., Hershey, Tamara, Janik, Piotr, Koller, Jonathan M., Martin-Rodriguez, Juan Francisco, Müller, Karsten, Palmucci, Stefano, Prato, Adriana, Ramkiran, Shukti, Saia, Federica, Szejko, Natalia, Torrecuso, Renzo, Tumer, Zeynep, Uhlmann, Anne, Veselinovic, Tanja, Wolańczyk, Tomasz, Zouki, Jade-Jocelyne, Jain, Pritesh, Topaloudi, Apostolia, Kaka, Mary, Yang, Zhiyu, Drineas, Petros, Thomopoulos, Sophia I., White, Tonya, Veltman, Dick J., Schmaal, Lianne, Stein, Dan J., Buitelaar, Jan, Franke, Barbara, van den Heuvel, Odile, Jahanshad, Neda, Thompson, Paul M., Black, Kevin J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9443935/
https://www.ncbi.nlm.nih.gov/pubmed/36072455
http://dx.doi.org/10.3389/fpsyt.2022.958688
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author Paschou, Peristera
Jin, Yin
Müller-Vahl, Kirsten
Möller, Harald E.
Rizzo, Renata
Hoekstra, Pieter J.
Roessner, Veit
Mol Debes, Nanette
Worbe, Yulia
Hartmann, Andreas
Mir, Pablo
Cath, Danielle
Neuner, Irene
Eichele, Heike
Zhang, Chencheng
Lewandowska, Katarzyna
Munchau, Alexander
Verrel, Julius
Musil, Richard
Silk, Tim J.
Hanlon, Colleen A.
Bihun, Emily D.
Brandt, Valerie
Dietrich, Andrea
Forde, Natalie
Ganos, Christos
Greene, Deanna J.
Chu, Chunguang
Grothe, Michel J.
Hershey, Tamara
Janik, Piotr
Koller, Jonathan M.
Martin-Rodriguez, Juan Francisco
Müller, Karsten
Palmucci, Stefano
Prato, Adriana
Ramkiran, Shukti
Saia, Federica
Szejko, Natalia
Torrecuso, Renzo
Tumer, Zeynep
Uhlmann, Anne
Veselinovic, Tanja
Wolańczyk, Tomasz
Zouki, Jade-Jocelyne
Jain, Pritesh
Topaloudi, Apostolia
Kaka, Mary
Yang, Zhiyu
Drineas, Petros
Thomopoulos, Sophia I.
White, Tonya
Veltman, Dick J.
Schmaal, Lianne
Stein, Dan J.
Buitelaar, Jan
Franke, Barbara
van den Heuvel, Odile
Jahanshad, Neda
Thompson, Paul M.
Black, Kevin J.
author_facet Paschou, Peristera
Jin, Yin
Müller-Vahl, Kirsten
Möller, Harald E.
Rizzo, Renata
Hoekstra, Pieter J.
Roessner, Veit
Mol Debes, Nanette
Worbe, Yulia
Hartmann, Andreas
Mir, Pablo
Cath, Danielle
Neuner, Irene
Eichele, Heike
Zhang, Chencheng
Lewandowska, Katarzyna
Munchau, Alexander
Verrel, Julius
Musil, Richard
Silk, Tim J.
Hanlon, Colleen A.
Bihun, Emily D.
Brandt, Valerie
Dietrich, Andrea
Forde, Natalie
Ganos, Christos
Greene, Deanna J.
Chu, Chunguang
Grothe, Michel J.
Hershey, Tamara
Janik, Piotr
Koller, Jonathan M.
Martin-Rodriguez, Juan Francisco
Müller, Karsten
Palmucci, Stefano
Prato, Adriana
Ramkiran, Shukti
Saia, Federica
Szejko, Natalia
Torrecuso, Renzo
Tumer, Zeynep
Uhlmann, Anne
Veselinovic, Tanja
Wolańczyk, Tomasz
Zouki, Jade-Jocelyne
Jain, Pritesh
Topaloudi, Apostolia
Kaka, Mary
Yang, Zhiyu
Drineas, Petros
Thomopoulos, Sophia I.
White, Tonya
Veltman, Dick J.
Schmaal, Lianne
Stein, Dan J.
Buitelaar, Jan
Franke, Barbara
van den Heuvel, Odile
Jahanshad, Neda
Thompson, Paul M.
Black, Kevin J.
author_sort Paschou, Peristera
collection PubMed
description Tourette syndrome (TS) is characterized by multiple motor and vocal tics, and high-comorbidity rates with other neuropsychiatric disorders. Obsessive compulsive disorder (OCD), attention deficit hyperactivity disorder (ADHD), autism spectrum disorders (ASDs), major depressive disorder (MDD), and anxiety disorders (AXDs) are among the most prevalent TS comorbidities. To date, studies on TS brain structure and function have been limited in size with efforts mostly fragmented. This leads to low-statistical power, discordant results due to differences in approaches, and hinders the ability to stratify patients according to clinical parameters and investigate comorbidity patterns. Here, we present the scientific premise, perspectives, and key goals that have motivated the establishment of the Enhancing Neuroimaging Genetics through Meta-Analysis for TS (ENIGMA-TS) working group. The ENIGMA-TS working group is an international collaborative effort bringing together a large network of investigators who aim to understand brain structure and function in TS and dissect the underlying neurobiology that leads to observed comorbidity patterns and clinical heterogeneity. Previously collected TS neuroimaging data will be analyzed jointly and integrated with TS genomic data, as well as equivalently large and already existing studies of highly comorbid OCD, ADHD, ASD, MDD, and AXD. Our work highlights the power of collaborative efforts and transdiagnostic approaches, and points to the existence of different TS subtypes. ENIGMA-TS will offer large-scale, high-powered studies that will lead to important insights toward understanding brain structure and function and genetic effects in TS and related disorders, and the identification of biomarkers that could help inform improved clinical practice.
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spelling pubmed-94439352022-09-06 Enhancing neuroimaging genetics through meta-analysis for Tourette syndrome (ENIGMA-TS): A worldwide platform for collaboration Paschou, Peristera Jin, Yin Müller-Vahl, Kirsten Möller, Harald E. Rizzo, Renata Hoekstra, Pieter J. Roessner, Veit Mol Debes, Nanette Worbe, Yulia Hartmann, Andreas Mir, Pablo Cath, Danielle Neuner, Irene Eichele, Heike Zhang, Chencheng Lewandowska, Katarzyna Munchau, Alexander Verrel, Julius Musil, Richard Silk, Tim J. Hanlon, Colleen A. Bihun, Emily D. Brandt, Valerie Dietrich, Andrea Forde, Natalie Ganos, Christos Greene, Deanna J. Chu, Chunguang Grothe, Michel J. Hershey, Tamara Janik, Piotr Koller, Jonathan M. Martin-Rodriguez, Juan Francisco Müller, Karsten Palmucci, Stefano Prato, Adriana Ramkiran, Shukti Saia, Federica Szejko, Natalia Torrecuso, Renzo Tumer, Zeynep Uhlmann, Anne Veselinovic, Tanja Wolańczyk, Tomasz Zouki, Jade-Jocelyne Jain, Pritesh Topaloudi, Apostolia Kaka, Mary Yang, Zhiyu Drineas, Petros Thomopoulos, Sophia I. White, Tonya Veltman, Dick J. Schmaal, Lianne Stein, Dan J. Buitelaar, Jan Franke, Barbara van den Heuvel, Odile Jahanshad, Neda Thompson, Paul M. Black, Kevin J. Front Psychiatry Psychiatry Tourette syndrome (TS) is characterized by multiple motor and vocal tics, and high-comorbidity rates with other neuropsychiatric disorders. Obsessive compulsive disorder (OCD), attention deficit hyperactivity disorder (ADHD), autism spectrum disorders (ASDs), major depressive disorder (MDD), and anxiety disorders (AXDs) are among the most prevalent TS comorbidities. To date, studies on TS brain structure and function have been limited in size with efforts mostly fragmented. This leads to low-statistical power, discordant results due to differences in approaches, and hinders the ability to stratify patients according to clinical parameters and investigate comorbidity patterns. Here, we present the scientific premise, perspectives, and key goals that have motivated the establishment of the Enhancing Neuroimaging Genetics through Meta-Analysis for TS (ENIGMA-TS) working group. The ENIGMA-TS working group is an international collaborative effort bringing together a large network of investigators who aim to understand brain structure and function in TS and dissect the underlying neurobiology that leads to observed comorbidity patterns and clinical heterogeneity. Previously collected TS neuroimaging data will be analyzed jointly and integrated with TS genomic data, as well as equivalently large and already existing studies of highly comorbid OCD, ADHD, ASD, MDD, and AXD. Our work highlights the power of collaborative efforts and transdiagnostic approaches, and points to the existence of different TS subtypes. ENIGMA-TS will offer large-scale, high-powered studies that will lead to important insights toward understanding brain structure and function and genetic effects in TS and related disorders, and the identification of biomarkers that could help inform improved clinical practice. Frontiers Media S.A. 2022-08-18 /pmc/articles/PMC9443935/ /pubmed/36072455 http://dx.doi.org/10.3389/fpsyt.2022.958688 Text en Copyright © 2022 Paschou, Jin, Müller-Vahl, Möller, Rizzo, Hoekstra, Roessner, Mol Debes, Worbe, Hartmann, Mir, Cath, Neuner, Eichele, Zhang, Lewandowska, Munchau, Verrel, Musil, Silk, Hanlon, Bihun, Brandt, Dietrich, Forde, Ganos, Greene, Chu, Grothe, Hershey, Janik, Koller, Martin-Rodriguez, Müller, Palmucci, Prato, Ramkiran, Saia, Szejko, Torrecuso, Tumer, Uhlmann, Veselinovic, Wolańczyk, Zouki, Jain, Topaloudi, Kaka, Yang, Drineas, Thomopoulos, White, Veltman, Schmaal, Stein, Buitelaar, Franke, van den Heuvel, Jahanshad, Thompson and Black. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Psychiatry
Paschou, Peristera
Jin, Yin
Müller-Vahl, Kirsten
Möller, Harald E.
Rizzo, Renata
Hoekstra, Pieter J.
Roessner, Veit
Mol Debes, Nanette
Worbe, Yulia
Hartmann, Andreas
Mir, Pablo
Cath, Danielle
Neuner, Irene
Eichele, Heike
Zhang, Chencheng
Lewandowska, Katarzyna
Munchau, Alexander
Verrel, Julius
Musil, Richard
Silk, Tim J.
Hanlon, Colleen A.
Bihun, Emily D.
Brandt, Valerie
Dietrich, Andrea
Forde, Natalie
Ganos, Christos
Greene, Deanna J.
Chu, Chunguang
Grothe, Michel J.
Hershey, Tamara
Janik, Piotr
Koller, Jonathan M.
Martin-Rodriguez, Juan Francisco
Müller, Karsten
Palmucci, Stefano
Prato, Adriana
Ramkiran, Shukti
Saia, Federica
Szejko, Natalia
Torrecuso, Renzo
Tumer, Zeynep
Uhlmann, Anne
Veselinovic, Tanja
Wolańczyk, Tomasz
Zouki, Jade-Jocelyne
Jain, Pritesh
Topaloudi, Apostolia
Kaka, Mary
Yang, Zhiyu
Drineas, Petros
Thomopoulos, Sophia I.
White, Tonya
Veltman, Dick J.
Schmaal, Lianne
Stein, Dan J.
Buitelaar, Jan
Franke, Barbara
van den Heuvel, Odile
Jahanshad, Neda
Thompson, Paul M.
Black, Kevin J.
Enhancing neuroimaging genetics through meta-analysis for Tourette syndrome (ENIGMA-TS): A worldwide platform for collaboration
title Enhancing neuroimaging genetics through meta-analysis for Tourette syndrome (ENIGMA-TS): A worldwide platform for collaboration
title_full Enhancing neuroimaging genetics through meta-analysis for Tourette syndrome (ENIGMA-TS): A worldwide platform for collaboration
title_fullStr Enhancing neuroimaging genetics through meta-analysis for Tourette syndrome (ENIGMA-TS): A worldwide platform for collaboration
title_full_unstemmed Enhancing neuroimaging genetics through meta-analysis for Tourette syndrome (ENIGMA-TS): A worldwide platform for collaboration
title_short Enhancing neuroimaging genetics through meta-analysis for Tourette syndrome (ENIGMA-TS): A worldwide platform for collaboration
title_sort enhancing neuroimaging genetics through meta-analysis for tourette syndrome (enigma-ts): a worldwide platform for collaboration
topic Psychiatry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9443935/
https://www.ncbi.nlm.nih.gov/pubmed/36072455
http://dx.doi.org/10.3389/fpsyt.2022.958688
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