Cargando…
Localization of ectopic and supernumerary parathyroid glands in patients with secondary and tertiary hyperparathyroidism: surgical description and correlation with preoperative ultrasonography and Tc99m-Sestamibi scintigraphy
INTRODUCTION: Hyperparathyroidism is an expected metabolic consequence of chronic kidney disease (CKD). Ectopic and/or supernumerary parathyroid glands (PT) may be the cause of surgical failure in patients undergoing total parathyroidectomy (PTX). AIM: To define the locations of ectopic and supernum...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9443960/ https://www.ncbi.nlm.nih.gov/pubmed/24626889 http://dx.doi.org/10.5935/1808-8694.20140008 |
_version_ | 1784783107593863168 |
---|---|
author | de Andrade, José Santos Cruz Mangussi-Gomes, João Paulo da Rocha, Lillian Andrade Ohe, Monique Nakayama Rosano, Marcello das Neves, Murilo Catafesta Santos, Rodrigo de Oliveira |
author_facet | de Andrade, José Santos Cruz Mangussi-Gomes, João Paulo da Rocha, Lillian Andrade Ohe, Monique Nakayama Rosano, Marcello das Neves, Murilo Catafesta Santos, Rodrigo de Oliveira |
author_sort | de Andrade, José Santos Cruz |
collection | PubMed |
description | INTRODUCTION: Hyperparathyroidism is an expected metabolic consequence of chronic kidney disease (CKD). Ectopic and/or supernumerary parathyroid glands (PT) may be the cause of surgical failure in patients undergoing total parathyroidectomy (PTX). AIM: To define the locations of ectopic and supernumerary PT in patients with renal hyperparathyroidism and to correlate intraoperative findings with preoperative tests. MATERIALS AND METHODS: A retrospective study was conducted with 166 patients submitted to PTX. The location of PT during surgery was recorded and classified as eutopic or ectopic. The preoperative localizations of PT found by ultrasonography (USG) and Tc99m-Sestamibi scintigraphy (MIBI) were subsequently compared with intraoperative findings. RESULTS: In the 166 patients studied, 664 PT were found. Five-hundred-seventy-seven (86.4%) glands were classified as eutopic and 91(13.6%) as ectopic. Eight supernumerary PT were found. The most common sites of ectopic PT were in the retroesophageal and thymic regions. Taken together, USG and MIBI did not identify 56 (61.5%) ectopic glands. MIBI was positive for 69,7% of all ectopic glands located in the mediastinal and thymic regions. CONCLUSION: The presence of ectopic and supernumerary PT in patients with renal hyperparathyroidism is significant. Although preoperative imaging tests did not locate most of ectopic glands, MIBI may be important for identifying ectopic PT in the mediastinal and thymic regions. |
format | Online Article Text |
id | pubmed-9443960 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-94439602022-09-09 Localization of ectopic and supernumerary parathyroid glands in patients with secondary and tertiary hyperparathyroidism: surgical description and correlation with preoperative ultrasonography and Tc99m-Sestamibi scintigraphy de Andrade, José Santos Cruz Mangussi-Gomes, João Paulo da Rocha, Lillian Andrade Ohe, Monique Nakayama Rosano, Marcello das Neves, Murilo Catafesta Santos, Rodrigo de Oliveira Braz J Otorhinolaryngol Original article INTRODUCTION: Hyperparathyroidism is an expected metabolic consequence of chronic kidney disease (CKD). Ectopic and/or supernumerary parathyroid glands (PT) may be the cause of surgical failure in patients undergoing total parathyroidectomy (PTX). AIM: To define the locations of ectopic and supernumerary PT in patients with renal hyperparathyroidism and to correlate intraoperative findings with preoperative tests. MATERIALS AND METHODS: A retrospective study was conducted with 166 patients submitted to PTX. The location of PT during surgery was recorded and classified as eutopic or ectopic. The preoperative localizations of PT found by ultrasonography (USG) and Tc99m-Sestamibi scintigraphy (MIBI) were subsequently compared with intraoperative findings. RESULTS: In the 166 patients studied, 664 PT were found. Five-hundred-seventy-seven (86.4%) glands were classified as eutopic and 91(13.6%) as ectopic. Eight supernumerary PT were found. The most common sites of ectopic PT were in the retroesophageal and thymic regions. Taken together, USG and MIBI did not identify 56 (61.5%) ectopic glands. MIBI was positive for 69,7% of all ectopic glands located in the mediastinal and thymic regions. CONCLUSION: The presence of ectopic and supernumerary PT in patients with renal hyperparathyroidism is significant. Although preoperative imaging tests did not locate most of ectopic glands, MIBI may be important for identifying ectopic PT in the mediastinal and thymic regions. Elsevier 2014-03-12 /pmc/articles/PMC9443960/ /pubmed/24626889 http://dx.doi.org/10.5935/1808-8694.20140008 Text en © 2014 Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial. Published by Elsevier Editora Ltda. All rights reserved. https://creativecommons.org/licenses/by-nc-nd/3.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/). |
spellingShingle | Original article de Andrade, José Santos Cruz Mangussi-Gomes, João Paulo da Rocha, Lillian Andrade Ohe, Monique Nakayama Rosano, Marcello das Neves, Murilo Catafesta Santos, Rodrigo de Oliveira Localization of ectopic and supernumerary parathyroid glands in patients with secondary and tertiary hyperparathyroidism: surgical description and correlation with preoperative ultrasonography and Tc99m-Sestamibi scintigraphy |
title | Localization of ectopic and supernumerary parathyroid glands in patients with secondary and tertiary hyperparathyroidism: surgical description and correlation with preoperative ultrasonography and Tc99m-Sestamibi scintigraphy |
title_full | Localization of ectopic and supernumerary parathyroid glands in patients with secondary and tertiary hyperparathyroidism: surgical description and correlation with preoperative ultrasonography and Tc99m-Sestamibi scintigraphy |
title_fullStr | Localization of ectopic and supernumerary parathyroid glands in patients with secondary and tertiary hyperparathyroidism: surgical description and correlation with preoperative ultrasonography and Tc99m-Sestamibi scintigraphy |
title_full_unstemmed | Localization of ectopic and supernumerary parathyroid glands in patients with secondary and tertiary hyperparathyroidism: surgical description and correlation with preoperative ultrasonography and Tc99m-Sestamibi scintigraphy |
title_short | Localization of ectopic and supernumerary parathyroid glands in patients with secondary and tertiary hyperparathyroidism: surgical description and correlation with preoperative ultrasonography and Tc99m-Sestamibi scintigraphy |
title_sort | localization of ectopic and supernumerary parathyroid glands in patients with secondary and tertiary hyperparathyroidism: surgical description and correlation with preoperative ultrasonography and tc99m-sestamibi scintigraphy |
topic | Original article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9443960/ https://www.ncbi.nlm.nih.gov/pubmed/24626889 http://dx.doi.org/10.5935/1808-8694.20140008 |
work_keys_str_mv | AT deandradejosesantoscruz localizationofectopicandsupernumeraryparathyroidglandsinpatientswithsecondaryandtertiaryhyperparathyroidismsurgicaldescriptionandcorrelationwithpreoperativeultrasonographyandtc99msestamibiscintigraphy AT mangussigomesjoaopaulo localizationofectopicandsupernumeraryparathyroidglandsinpatientswithsecondaryandtertiaryhyperparathyroidismsurgicaldescriptionandcorrelationwithpreoperativeultrasonographyandtc99msestamibiscintigraphy AT darochalillianandrade localizationofectopicandsupernumeraryparathyroidglandsinpatientswithsecondaryandtertiaryhyperparathyroidismsurgicaldescriptionandcorrelationwithpreoperativeultrasonographyandtc99msestamibiscintigraphy AT ohemoniquenakayama localizationofectopicandsupernumeraryparathyroidglandsinpatientswithsecondaryandtertiaryhyperparathyroidismsurgicaldescriptionandcorrelationwithpreoperativeultrasonographyandtc99msestamibiscintigraphy AT rosanomarcello localizationofectopicandsupernumeraryparathyroidglandsinpatientswithsecondaryandtertiaryhyperparathyroidismsurgicaldescriptionandcorrelationwithpreoperativeultrasonographyandtc99msestamibiscintigraphy AT dasnevesmurilocatafesta localizationofectopicandsupernumeraryparathyroidglandsinpatientswithsecondaryandtertiaryhyperparathyroidismsurgicaldescriptionandcorrelationwithpreoperativeultrasonographyandtc99msestamibiscintigraphy AT santosrodrigodeoliveira localizationofectopicandsupernumeraryparathyroidglandsinpatientswithsecondaryandtertiaryhyperparathyroidismsurgicaldescriptionandcorrelationwithpreoperativeultrasonographyandtc99msestamibiscintigraphy |