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Processing DNA lesions during mitosis to prevent genomic instability

Failure of cells to process toxic double-strand breaks (DSBs) constitutes a major intrinsic source of genome instability, a hallmark of cancer. In contrast with interphase of the cell cycle, canonical repair pathways in response to DSBs are inactivated in mitosis. Although cell cycle checkpoints pre...

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Detalles Bibliográficos
Autores principales:	Audrey, Anastasia, de Haan, Lauren, van Vugt, Marcel A.T.M., de Boer, H. Rudolf
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Portland Press Ltd. 2022
Materias:	Review Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9444068/ https://www.ncbi.nlm.nih.gov/pubmed/36040211 http://dx.doi.org/10.1042/BST20220049

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