Antibody titers and neutralizing activity in cases of COVID-19 after a single dose of vaccination

Vaccines for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have shown high efficacy in preventing the onset of disease. However, the immune response to infection immediately after the first vaccination remains unknown. We examined the anti-SARS-CoV-2-binding-antibody titers and neutra...

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Autores principales: Okumura, Nobumasa, Saito, Sho, Takamatsu, Yuki, Takeuchi, Junko S., Asai, Yusuke, Sanada, Mio, Iwamoto, Noriko, Maeda, Kenji, Mitsuya, Hiroaki, Ohmagari, Norio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. 2022
Materias:
Note
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9444155/
https://www.ncbi.nlm.nih.gov/pubmed/36067912
http://dx.doi.org/10.1016/j.jiac.2022.08.026
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author Okumura, Nobumasa
Saito, Sho
Takamatsu, Yuki
Takeuchi, Junko S.
Asai, Yusuke
Sanada, Mio
Iwamoto, Noriko
Maeda, Kenji
Mitsuya, Hiroaki
Ohmagari, Norio
author_facet Okumura, Nobumasa
Saito, Sho
Takamatsu, Yuki
Takeuchi, Junko S.
Asai, Yusuke
Sanada, Mio
Iwamoto, Noriko
Maeda, Kenji
Mitsuya, Hiroaki
Ohmagari, Norio
author_sort Okumura, Nobumasa
collection PubMed
description Vaccines for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have shown high efficacy in preventing the onset of disease. However, the immune response to infection immediately after the first vaccination remains unknown. We examined the anti-SARS-CoV-2-binding-antibody titers and neutralizing activity in patients who developed coronavirus disease 2019 after the first vaccination. The amount of anti-SARS-CoV-2-binding antibodies and neutralizing activity drastically increased from the first to the second collection. Our results may provide important data on the course of immune response following vaccination.
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spelling pubmed-94441552022-09-06 Antibody titers and neutralizing activity in cases of COVID-19 after a single dose of vaccination Okumura, Nobumasa Saito, Sho Takamatsu, Yuki Takeuchi, Junko S. Asai, Yusuke Sanada, Mio Iwamoto, Noriko Maeda, Kenji Mitsuya, Hiroaki Ohmagari, Norio J Infect Chemother Note Vaccines for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have shown high efficacy in preventing the onset of disease. However, the immune response to infection immediately after the first vaccination remains unknown. We examined the anti-SARS-CoV-2-binding-antibody titers and neutralizing activity in patients who developed coronavirus disease 2019 after the first vaccination. The amount of anti-SARS-CoV-2-binding antibodies and neutralizing activity drastically increased from the first to the second collection. Our results may provide important data on the course of immune response following vaccination. Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. 2022-12 2022-09-05 /pmc/articles/PMC9444155/ /pubmed/36067912 http://dx.doi.org/10.1016/j.jiac.2022.08.026 Text en © 2022 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Note
Okumura, Nobumasa
Saito, Sho
Takamatsu, Yuki
Takeuchi, Junko S.
Asai, Yusuke
Sanada, Mio
Iwamoto, Noriko
Maeda, Kenji
Mitsuya, Hiroaki
Ohmagari, Norio
Antibody titers and neutralizing activity in cases of COVID-19 after a single dose of vaccination
title Antibody titers and neutralizing activity in cases of COVID-19 after a single dose of vaccination
title_full Antibody titers and neutralizing activity in cases of COVID-19 after a single dose of vaccination
title_fullStr Antibody titers and neutralizing activity in cases of COVID-19 after a single dose of vaccination
title_full_unstemmed Antibody titers and neutralizing activity in cases of COVID-19 after a single dose of vaccination
title_short Antibody titers and neutralizing activity in cases of COVID-19 after a single dose of vaccination
title_sort antibody titers and neutralizing activity in cases of covid-19 after a single dose of vaccination
topic Note
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9444155/
https://www.ncbi.nlm.nih.gov/pubmed/36067912
http://dx.doi.org/10.1016/j.jiac.2022.08.026
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