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Amygdala-cortical collaboration in reward learning and decision making

Adaptive reward-related decision making requires accurate prospective consideration of the specific outcome of each option and its current desirability. These mental simulations are informed by stored memories of the associative relationships that exist within an environment. In this review, I discu...

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Autor principal: Wassum, Kate M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9444241/
https://www.ncbi.nlm.nih.gov/pubmed/36062909
http://dx.doi.org/10.7554/eLife.80926
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author Wassum, Kate M
author_facet Wassum, Kate M
author_sort Wassum, Kate M
collection PubMed
description Adaptive reward-related decision making requires accurate prospective consideration of the specific outcome of each option and its current desirability. These mental simulations are informed by stored memories of the associative relationships that exist within an environment. In this review, I discuss recent investigations of the function of circuitry between the basolateral amygdala (BLA) and lateral (lOFC) and medial (mOFC) orbitofrontal cortex in the learning and use of associative reward memories. I draw conclusions from data collected using sophisticated behavioral approaches to diagnose the content of appetitive memory in combination with modern circuit dissection tools. I propose that, via their direct bidirectional connections, the BLA and OFC collaborate to help us encode detailed, outcome-specific, state-dependent reward memories and to use those memories to enable the predictions and inferences that support adaptive decision making. Whereas lOFC→BLA projections mediate the encoding of outcome-specific reward memories, mOFC→BLA projections regulate the ability to use these memories to inform reward pursuit decisions. BLA projections to lOFC and mOFC both contribute to using reward memories to guide decision making. The BLA→lOFC pathway mediates the ability to represent the identity of a specific predicted reward and the BLA→mOFC pathway facilitates understanding of the value of predicted events. Thus, I outline a neuronal circuit architecture for reward learning and decision making and provide new testable hypotheses as well as implications for both adaptive and maladaptive decision making.
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spelling pubmed-94442412022-09-06 Amygdala-cortical collaboration in reward learning and decision making Wassum, Kate M eLife Neuroscience Adaptive reward-related decision making requires accurate prospective consideration of the specific outcome of each option and its current desirability. These mental simulations are informed by stored memories of the associative relationships that exist within an environment. In this review, I discuss recent investigations of the function of circuitry between the basolateral amygdala (BLA) and lateral (lOFC) and medial (mOFC) orbitofrontal cortex in the learning and use of associative reward memories. I draw conclusions from data collected using sophisticated behavioral approaches to diagnose the content of appetitive memory in combination with modern circuit dissection tools. I propose that, via their direct bidirectional connections, the BLA and OFC collaborate to help us encode detailed, outcome-specific, state-dependent reward memories and to use those memories to enable the predictions and inferences that support adaptive decision making. Whereas lOFC→BLA projections mediate the encoding of outcome-specific reward memories, mOFC→BLA projections regulate the ability to use these memories to inform reward pursuit decisions. BLA projections to lOFC and mOFC both contribute to using reward memories to guide decision making. The BLA→lOFC pathway mediates the ability to represent the identity of a specific predicted reward and the BLA→mOFC pathway facilitates understanding of the value of predicted events. Thus, I outline a neuronal circuit architecture for reward learning and decision making and provide new testable hypotheses as well as implications for both adaptive and maladaptive decision making. eLife Sciences Publications, Ltd 2022-09-05 /pmc/articles/PMC9444241/ /pubmed/36062909 http://dx.doi.org/10.7554/eLife.80926 Text en © 2022, Wassum https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Neuroscience
Wassum, Kate M
Amygdala-cortical collaboration in reward learning and decision making
title Amygdala-cortical collaboration in reward learning and decision making
title_full Amygdala-cortical collaboration in reward learning and decision making
title_fullStr Amygdala-cortical collaboration in reward learning and decision making
title_full_unstemmed Amygdala-cortical collaboration in reward learning and decision making
title_short Amygdala-cortical collaboration in reward learning and decision making
title_sort amygdala-cortical collaboration in reward learning and decision making
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9444241/
https://www.ncbi.nlm.nih.gov/pubmed/36062909
http://dx.doi.org/10.7554/eLife.80926
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