Multiple ciliary localization signals control INPP5E ciliary targeting

Primary cilia are sensory membrane protrusions whose dysfunction causes ciliopathies. INPP5E is a ciliary phosphoinositide phosphatase mutated in ciliopathies like Joubert syndrome. INPP5E regulates numerous ciliary functions, but how it accumulates in cilia remains poorly understood. Herein, we sho...

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Detalles Bibliográficos
Autores principales: Cilleros-Rodriguez, Dario, Martin-Morales, Raquel, Barbeito, Pablo, Deb Roy, Abhijit, Loukil, Abdelhalim, Sierra-Rodero, Belen, Herranz, Gonzalo, Pampliega, Olatz, Redrejo-Rodriguez, Modesto, Goetz, Sarah C, Izquierdo, Manuel, Inoue, Takanari, Garcia-Gonzalo, Francesc R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9444247/
https://www.ncbi.nlm.nih.gov/pubmed/36063381
http://dx.doi.org/10.7554/eLife.78383

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