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Hemophilia B acquired after cadaveric liver transplantation: a case report

Hemophilia B is a recessive hereditary disease, and manifestations result from coagulation factor IX deficiency. Although improbable, as factor IX is produced exclusively in the liver, the possibility of developing the disease after transplantation represents an infrequent but potentially morbid com...

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Detalles Bibliográficos
Autores principales: Machado e Silva Gomide, Larissa, Weihermann, Viktoria, de Oliveira, Isabella Corrêa, Nissel, Maria Alice Zarate, Valejo, Igor Raphael Mathias, da Silva Wolff, Lucas, de Aguiar, Alan Junior, Verona, Dunia, Degraf, Ygor, de Carvalho Arouca, Julianna Storace, Barros Sanches, João Paulo, Cabral, Rodrigo Rezende Silva, Kampa, Katia Cristina, de Freitas, Alexandre Coutinho Teixeira, Tefili, Nertan Luiz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9444287/
https://www.ncbi.nlm.nih.gov/pubmed/36071731
http://dx.doi.org/10.1093/jscr/rjac393
Descripción
Sumario:Hemophilia B is a recessive hereditary disease, and manifestations result from coagulation factor IX deficiency. Although improbable, as factor IX is produced exclusively in the liver, the possibility of developing the disease after transplantation represents an infrequent but potentially morbid complication. Standard laboratory tests may be insufficient to determine the probability of transmission of this pathology. This report describes the case of a patient who developed hemophilia B after liver transplantation whose donor had no prior knowledge of the disease.