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Translocator Protein 18 kDa (TSPO) as a Novel Therapeutic Target for Chronic Pain
Chronic pain is an enormous modern public health problem, with significant numbers of people debilitated by chronic pain from a variety of etiologies. Translocator protein 18 kDa (TSPO) was discovered in 1977 as a peripheral benzodiazepine receptor. It is a five transmembrane domain protein, mainly...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9444456/ https://www.ncbi.nlm.nih.gov/pubmed/36071748 http://dx.doi.org/10.1155/2022/8057854 |
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author | Liu, Jie Huang, Jingyao Zhang, Zhenjiang Zhang, Rui Zhang, Zhihao Liu, Yongxin Ma, Baoyu |
author_facet | Liu, Jie Huang, Jingyao Zhang, Zhenjiang Zhang, Rui Zhang, Zhihao Liu, Yongxin Ma, Baoyu |
author_sort | Liu, Jie |
collection | PubMed |
description | Chronic pain is an enormous modern public health problem, with significant numbers of people debilitated by chronic pain from a variety of etiologies. Translocator protein 18 kDa (TSPO) was discovered in 1977 as a peripheral benzodiazepine receptor. It is a five transmembrane domain protein, mainly localized in the outer mitochondrial membrane. Recent and increasing studies have found changes in TSPO and its ligands in various chronic pain models. Reversing their expressions has been shown to alleviate chronic pain in these models, illustrating the effects of TSPO and its ligands. Herein, we review recent evidence and the mechanisms of TSPO in the development of chronic pain associated with peripheral nerve injury, spinal cord injury, cancer, and inflammatory responses. The cumulative evidence indicates that TSPO-based therapy may become an alternative strategy for treating chronic pain. |
format | Online Article Text |
id | pubmed-9444456 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-94444562022-09-06 Translocator Protein 18 kDa (TSPO) as a Novel Therapeutic Target for Chronic Pain Liu, Jie Huang, Jingyao Zhang, Zhenjiang Zhang, Rui Zhang, Zhihao Liu, Yongxin Ma, Baoyu Neural Plast Review Article Chronic pain is an enormous modern public health problem, with significant numbers of people debilitated by chronic pain from a variety of etiologies. Translocator protein 18 kDa (TSPO) was discovered in 1977 as a peripheral benzodiazepine receptor. It is a five transmembrane domain protein, mainly localized in the outer mitochondrial membrane. Recent and increasing studies have found changes in TSPO and its ligands in various chronic pain models. Reversing their expressions has been shown to alleviate chronic pain in these models, illustrating the effects of TSPO and its ligands. Herein, we review recent evidence and the mechanisms of TSPO in the development of chronic pain associated with peripheral nerve injury, spinal cord injury, cancer, and inflammatory responses. The cumulative evidence indicates that TSPO-based therapy may become an alternative strategy for treating chronic pain. Hindawi 2022-08-29 /pmc/articles/PMC9444456/ /pubmed/36071748 http://dx.doi.org/10.1155/2022/8057854 Text en Copyright © 2022 Jie Liu et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Liu, Jie Huang, Jingyao Zhang, Zhenjiang Zhang, Rui Zhang, Zhihao Liu, Yongxin Ma, Baoyu Translocator Protein 18 kDa (TSPO) as a Novel Therapeutic Target for Chronic Pain |
title | Translocator Protein 18 kDa (TSPO) as a Novel Therapeutic Target for Chronic Pain |
title_full | Translocator Protein 18 kDa (TSPO) as a Novel Therapeutic Target for Chronic Pain |
title_fullStr | Translocator Protein 18 kDa (TSPO) as a Novel Therapeutic Target for Chronic Pain |
title_full_unstemmed | Translocator Protein 18 kDa (TSPO) as a Novel Therapeutic Target for Chronic Pain |
title_short | Translocator Protein 18 kDa (TSPO) as a Novel Therapeutic Target for Chronic Pain |
title_sort | translocator protein 18 kda (tspo) as a novel therapeutic target for chronic pain |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9444456/ https://www.ncbi.nlm.nih.gov/pubmed/36071748 http://dx.doi.org/10.1155/2022/8057854 |
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