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Antioxidant therapy in the elderly with tinnitus()()
INTRODUCTION: Several approaches have been tried for the treatment of tinnitus, from cognitive-behavioral therapies and sound enrichment to medication. In this context, antioxidants, widely used in numerous areas of medicine, appear to represent a promising approach for the control of this symptom,...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9444615/ https://www.ncbi.nlm.nih.gov/pubmed/26547700 http://dx.doi.org/10.1016/j.bjorl.2015.04.016 |
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author | Polanski, José Fernando Soares, Alexandra Dezani de Mendonça Cruz, Oswaldo Laércio |
author_facet | Polanski, José Fernando Soares, Alexandra Dezani de Mendonça Cruz, Oswaldo Laércio |
author_sort | Polanski, José Fernando |
collection | PubMed |
description | INTRODUCTION: Several approaches have been tried for the treatment of tinnitus, from cognitive-behavioral therapies and sound enrichment to medication. In this context, antioxidants, widely used in numerous areas of medicine, appear to represent a promising approach for the control of this symptom, which often is poorly controlled. OBJECTIVE: To evaluate the effects of antioxidant therapy for tinnitus in a group of elderly patients. METHODS: Prospective, randomized, double-blinded, placebo-controlled clinical trial. The sample consisted of 58 subjects aged 60 years or older, with a complaint of tinnitus associated with sensorineural hearing loss. These individuals completed the Tinnitus Handicap Inventory (THI) questionnaire before and after six months of therapy. The treatment regimens were: Ginkgo biloba dry extract (120 mg/day), α-lipoic acid (60 mg/day) + vitamin C (600 mg/day), papaverine hydrochloride (100 mg/day) + vitamin E (400 mg/day), and placebo. RESULTS: There was no statistically significant difference between THI by degree (p = 0.441) and by score (p = 0.848) before and after treatment. CONCLUSION: There was no benefit from the use of antioxidant agents for tinnitus in this sample. |
format | Online Article Text |
id | pubmed-9444615 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-94446152022-09-09 Antioxidant therapy in the elderly with tinnitus()() Polanski, José Fernando Soares, Alexandra Dezani de Mendonça Cruz, Oswaldo Laércio Braz J Otorhinolaryngol Original Article INTRODUCTION: Several approaches have been tried for the treatment of tinnitus, from cognitive-behavioral therapies and sound enrichment to medication. In this context, antioxidants, widely used in numerous areas of medicine, appear to represent a promising approach for the control of this symptom, which often is poorly controlled. OBJECTIVE: To evaluate the effects of antioxidant therapy for tinnitus in a group of elderly patients. METHODS: Prospective, randomized, double-blinded, placebo-controlled clinical trial. The sample consisted of 58 subjects aged 60 years or older, with a complaint of tinnitus associated with sensorineural hearing loss. These individuals completed the Tinnitus Handicap Inventory (THI) questionnaire before and after six months of therapy. The treatment regimens were: Ginkgo biloba dry extract (120 mg/day), α-lipoic acid (60 mg/day) + vitamin C (600 mg/day), papaverine hydrochloride (100 mg/day) + vitamin E (400 mg/day), and placebo. RESULTS: There was no statistically significant difference between THI by degree (p = 0.441) and by score (p = 0.848) before and after treatment. CONCLUSION: There was no benefit from the use of antioxidant agents for tinnitus in this sample. Elsevier 2015-10-17 /pmc/articles/PMC9444615/ /pubmed/26547700 http://dx.doi.org/10.1016/j.bjorl.2015.04.016 Text en © 2015 Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial. Published by Elsevier Editora Ltda. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Original Article Polanski, José Fernando Soares, Alexandra Dezani de Mendonça Cruz, Oswaldo Laércio Antioxidant therapy in the elderly with tinnitus()() |
title | Antioxidant therapy in the elderly with tinnitus()() |
title_full | Antioxidant therapy in the elderly with tinnitus()() |
title_fullStr | Antioxidant therapy in the elderly with tinnitus()() |
title_full_unstemmed | Antioxidant therapy in the elderly with tinnitus()() |
title_short | Antioxidant therapy in the elderly with tinnitus()() |
title_sort | antioxidant therapy in the elderly with tinnitus()() |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9444615/ https://www.ncbi.nlm.nih.gov/pubmed/26547700 http://dx.doi.org/10.1016/j.bjorl.2015.04.016 |
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