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Clinical and otorhinolaryngological aspects of extranodal NK/T cell lymphoma, nasal type()()

INTRODUCTION: Extranodal NK/T-Cell lymphoma, nasal type (NKTLN) is a disease that mainly affects the nasal cavity and the paranasal sinuses. Early nasal symptoms are nonspecific, simulating sinus infection. With disease progression, necrosis of the nasal mucosa increases, hindering histological diag...

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Autores principales: Miyake, Marcel Menon, Oliveira, Mariana Vendramini Castrignano de, Miyake, Michelle Menon, Garcia, Julio Oliva de Almeida, Granato, Lidio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9444635/
https://www.ncbi.nlm.nih.gov/pubmed/25183183
http://dx.doi.org/10.1016/j.bjorl.2014.05.013
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author Miyake, Marcel Menon
Oliveira, Mariana Vendramini Castrignano de
Miyake, Michelle Menon
Garcia, Julio Oliva de Almeida
Granato, Lidio
author_facet Miyake, Marcel Menon
Oliveira, Mariana Vendramini Castrignano de
Miyake, Michelle Menon
Garcia, Julio Oliva de Almeida
Granato, Lidio
author_sort Miyake, Marcel Menon
collection PubMed
description INTRODUCTION: Extranodal NK/T-Cell lymphoma, nasal type (NKTLN) is a disease that mainly affects the nasal cavity and the paranasal sinuses. Early nasal symptoms are nonspecific, simulating sinus infection. With disease progression, necrosis of the nasal mucosa increases, hindering histological diagnosis. Thus, multiple biopsies may be necessary until definitive diagnosis. Most studies on NKTLN address the hematological and immunological aspects of the disease. OBJECTIVES: To present data from a Brazilian quaternary hospital, with emphasis on the clinical aspects of the disease, and to correlate the findings with the most recent literature data. METHODS: Case study of seven patient files. RESULTS: Patients were evaluated on their medical history, number of biopsies necessary, association with Epstein–Barr virus, treatment, and outcome. All patients had nonspecific nasal complaints and underwent at least three cycles of antibiotic therapy. The earlier a biopsy was performed, the fewer biopsies were required to diagnose the disease and start treatment. However, this fact did not translate into better prognosis. CONCLUSION: The otolaryngologist plays a fundamental role in the prognosis of NKTLN and can shorten time between symptom onset and treatment of the patient.
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spelling pubmed-94446352022-09-09 Clinical and otorhinolaryngological aspects of extranodal NK/T cell lymphoma, nasal type()() Miyake, Marcel Menon Oliveira, Mariana Vendramini Castrignano de Miyake, Michelle Menon Garcia, Julio Oliva de Almeida Granato, Lidio Braz J Otorhinolaryngol Original Article INTRODUCTION: Extranodal NK/T-Cell lymphoma, nasal type (NKTLN) is a disease that mainly affects the nasal cavity and the paranasal sinuses. Early nasal symptoms are nonspecific, simulating sinus infection. With disease progression, necrosis of the nasal mucosa increases, hindering histological diagnosis. Thus, multiple biopsies may be necessary until definitive diagnosis. Most studies on NKTLN address the hematological and immunological aspects of the disease. OBJECTIVES: To present data from a Brazilian quaternary hospital, with emphasis on the clinical aspects of the disease, and to correlate the findings with the most recent literature data. METHODS: Case study of seven patient files. RESULTS: Patients were evaluated on their medical history, number of biopsies necessary, association with Epstein–Barr virus, treatment, and outcome. All patients had nonspecific nasal complaints and underwent at least three cycles of antibiotic therapy. The earlier a biopsy was performed, the fewer biopsies were required to diagnose the disease and start treatment. However, this fact did not translate into better prognosis. CONCLUSION: The otolaryngologist plays a fundamental role in the prognosis of NKTLN and can shorten time between symptom onset and treatment of the patient. Elsevier 2014-06-11 /pmc/articles/PMC9444635/ /pubmed/25183183 http://dx.doi.org/10.1016/j.bjorl.2014.05.013 Text en © 2014 Associac¸ão Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial. Published by Elsevier Editora Ltda. All rights reserved. https://creativecommons.org/licenses/by-nc-nd/3.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).
spellingShingle Original Article
Miyake, Marcel Menon
Oliveira, Mariana Vendramini Castrignano de
Miyake, Michelle Menon
Garcia, Julio Oliva de Almeida
Granato, Lidio
Clinical and otorhinolaryngological aspects of extranodal NK/T cell lymphoma, nasal type()()
title Clinical and otorhinolaryngological aspects of extranodal NK/T cell lymphoma, nasal type()()
title_full Clinical and otorhinolaryngological aspects of extranodal NK/T cell lymphoma, nasal type()()
title_fullStr Clinical and otorhinolaryngological aspects of extranodal NK/T cell lymphoma, nasal type()()
title_full_unstemmed Clinical and otorhinolaryngological aspects of extranodal NK/T cell lymphoma, nasal type()()
title_short Clinical and otorhinolaryngological aspects of extranodal NK/T cell lymphoma, nasal type()()
title_sort clinical and otorhinolaryngological aspects of extranodal nk/t cell lymphoma, nasal type()()
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9444635/
https://www.ncbi.nlm.nih.gov/pubmed/25183183
http://dx.doi.org/10.1016/j.bjorl.2014.05.013
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