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Predictive Value of the ABCD3-I for Short- and Long-Term Stroke after TIA with or without sICAS

Aims: We aimed to validate the predictive value of the ABCD3-I score for short-term and long-term stroke risk after transient ischemic attack (TIA) and to evaluate the influence of symptomatic intracranial artery stenosis (sICAS) on the performance of ABCD3-I. Methods: We recruited TIA patients from...

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Autores principales: Xie, Xuewei, Jing, Jing, Meng, Xia, Li, Zixiao, Chen, Pan, Zhao, Xingquan, Wang, Yilong, Liu, Liping, Jiang, Yong, Pan, Yuesong, Jin, Aoming, Li, Hao, Wang, Yongjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Japan Atherosclerosis Society 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9444691/
https://www.ncbi.nlm.nih.gov/pubmed/34744099
http://dx.doi.org/10.5551/jat.63050
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author Xie, Xuewei
Jing, Jing
Meng, Xia
Li, Zixiao
Chen, Pan
Zhao, Xingquan
Wang, Yilong
Liu, Liping
Jiang, Yong
Pan, Yuesong
Jin, Aoming
Li, Hao
Wang, Yongjun
author_facet Xie, Xuewei
Jing, Jing
Meng, Xia
Li, Zixiao
Chen, Pan
Zhao, Xingquan
Wang, Yilong
Liu, Liping
Jiang, Yong
Pan, Yuesong
Jin, Aoming
Li, Hao
Wang, Yongjun
author_sort Xie, Xuewei
collection PubMed
description Aims: We aimed to validate the predictive value of the ABCD3-I score for short-term and long-term stroke risk after transient ischemic attack (TIA) and to evaluate the influence of symptomatic intracranial artery stenosis (sICAS) on the performance of ABCD3-I. Methods: We recruited TIA patients from the Third China National Stroke Registry study. Outcome parameters were stroke events during the 14-day, 3-month, 6-month, and 12-month points. The area under the curve (AUC) was calculated as a measure of predictive ability. A multivariable-adjusted Cox proportional hazards model was used to assess the hazard ratio of risk factors for stroke. Results: Among 986 patients, 3.9%, 5.1%, 6.5 %, and 8.2% of participants experienced a stroke event during the 14-day, 3-month, 6-month, and 12-month points post TIA, respectively. The AUCs of ABCD3-I score for the prediction of stroke were 0.786, 0.732, 0.715, and 0.699 at the 14-day, 3-month, 6-month, and 12-month points, respectively. The AUCs were 0.774, 0.690, 0.617, and 0.611 in patients with sICAS, 0.789, 0.748, and 0.758 and 0.734 in those without sICAS. P values of the interaction between ABCD3-I categories and sICAS were 0.0618 for 14-day, 0.0098 for 3-month, 0.0318 for 6-month, and 0.0294 for 12-month. Conclusions: ABCD3-I score performed well in predicting short-term risk of a stroke after an index TIA in patients with or without sICAS. However, the predictive power decayed with the prolonged period, and the decayed extent was more pronounced among those with sICAS. The assessment of sICAS is a non-ignorable item when using the ABCD3-I score for long-term stroke risk prediction in patients with TIA.
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spelling pubmed-94446912022-09-16 Predictive Value of the ABCD3-I for Short- and Long-Term Stroke after TIA with or without sICAS Xie, Xuewei Jing, Jing Meng, Xia Li, Zixiao Chen, Pan Zhao, Xingquan Wang, Yilong Liu, Liping Jiang, Yong Pan, Yuesong Jin, Aoming Li, Hao Wang, Yongjun J Atheroscler Thromb Original Article Aims: We aimed to validate the predictive value of the ABCD3-I score for short-term and long-term stroke risk after transient ischemic attack (TIA) and to evaluate the influence of symptomatic intracranial artery stenosis (sICAS) on the performance of ABCD3-I. Methods: We recruited TIA patients from the Third China National Stroke Registry study. Outcome parameters were stroke events during the 14-day, 3-month, 6-month, and 12-month points. The area under the curve (AUC) was calculated as a measure of predictive ability. A multivariable-adjusted Cox proportional hazards model was used to assess the hazard ratio of risk factors for stroke. Results: Among 986 patients, 3.9%, 5.1%, 6.5 %, and 8.2% of participants experienced a stroke event during the 14-day, 3-month, 6-month, and 12-month points post TIA, respectively. The AUCs of ABCD3-I score for the prediction of stroke were 0.786, 0.732, 0.715, and 0.699 at the 14-day, 3-month, 6-month, and 12-month points, respectively. The AUCs were 0.774, 0.690, 0.617, and 0.611 in patients with sICAS, 0.789, 0.748, and 0.758 and 0.734 in those without sICAS. P values of the interaction between ABCD3-I categories and sICAS were 0.0618 for 14-day, 0.0098 for 3-month, 0.0318 for 6-month, and 0.0294 for 12-month. Conclusions: ABCD3-I score performed well in predicting short-term risk of a stroke after an index TIA in patients with or without sICAS. However, the predictive power decayed with the prolonged period, and the decayed extent was more pronounced among those with sICAS. The assessment of sICAS is a non-ignorable item when using the ABCD3-I score for long-term stroke risk prediction in patients with TIA. Japan Atherosclerosis Society 2022-09-01 2021-11-06 /pmc/articles/PMC9444691/ /pubmed/34744099 http://dx.doi.org/10.5551/jat.63050 Text en 2022 Japan Atherosclerosis Society https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of the latest version of CC BY-NC-SA defined by the Creative Commons Attribution License.http://creativecommons.org/licenses/by-nc-sa/4.0/ (https://creativecommons.org/licenses/by-nc-sa/4.0/)
spellingShingle Original Article
Xie, Xuewei
Jing, Jing
Meng, Xia
Li, Zixiao
Chen, Pan
Zhao, Xingquan
Wang, Yilong
Liu, Liping
Jiang, Yong
Pan, Yuesong
Jin, Aoming
Li, Hao
Wang, Yongjun
Predictive Value of the ABCD3-I for Short- and Long-Term Stroke after TIA with or without sICAS
title Predictive Value of the ABCD3-I for Short- and Long-Term Stroke after TIA with or without sICAS
title_full Predictive Value of the ABCD3-I for Short- and Long-Term Stroke after TIA with or without sICAS
title_fullStr Predictive Value of the ABCD3-I for Short- and Long-Term Stroke after TIA with or without sICAS
title_full_unstemmed Predictive Value of the ABCD3-I for Short- and Long-Term Stroke after TIA with or without sICAS
title_short Predictive Value of the ABCD3-I for Short- and Long-Term Stroke after TIA with or without sICAS
title_sort predictive value of the abcd3-i for short- and long-term stroke after tia with or without sicas
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9444691/
https://www.ncbi.nlm.nih.gov/pubmed/34744099
http://dx.doi.org/10.5551/jat.63050
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