Adipocyte-derived lactate is a signalling metabolite that potentiates adipose macrophage inflammation via targeting PHD2

Adipose tissue macrophage (ATM) inflammation is involved with meta-inflammation and pathology of metabolic complications. Here we report that in adipocytes, elevated lactate production, previously regarded as the waste product of glycolysis, serves as a danger signal to promote ATM polarization to a...

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Detalles Bibliográficos
Autores principales: Feng, Tianshi, Zhao, Xuemei, Gu, Ping, Yang, Wah, Wang, Cunchuan, Guo, Qingyu, Long, Qiaoyun, Liu, Qing, Cheng, Ying, Li, Jin, Cheung, Cynthia Kwan Yui, Wu, Donghai, Kong, Xinyu, Xu, Yong, Ye, Dewei, Hua, Shuang, Loomes, Kerry, Xu, Aimin, Hui, Xiaoyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9445001/
https://www.ncbi.nlm.nih.gov/pubmed/36064857
http://dx.doi.org/10.1038/s41467-022-32871-3

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