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High-density electrode recordings reveal strong and specific connections between retinal ganglion cells and midbrain neurons

The superior colliculus is a midbrain structure that plays important roles in visually guided behaviors in mammals. Neurons in the superior colliculus receive inputs from retinal ganglion cells but how these inputs are integrated in vivo is unknown. Here, we discovered that high-density electrodes s...

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Autores principales: Sibille, Jérémie, Gehr, Carolin, Benichov, Jonathan I., Balasubramanian, Hymavathy, Teh, Kai Lun, Lupashina, Tatiana, Vallentin, Daniela, Kremkow, Jens
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9445019/
https://www.ncbi.nlm.nih.gov/pubmed/36064789
http://dx.doi.org/10.1038/s41467-022-32775-2
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author Sibille, Jérémie
Gehr, Carolin
Benichov, Jonathan I.
Balasubramanian, Hymavathy
Teh, Kai Lun
Lupashina, Tatiana
Vallentin, Daniela
Kremkow, Jens
author_facet Sibille, Jérémie
Gehr, Carolin
Benichov, Jonathan I.
Balasubramanian, Hymavathy
Teh, Kai Lun
Lupashina, Tatiana
Vallentin, Daniela
Kremkow, Jens
author_sort Sibille, Jérémie
collection PubMed
description The superior colliculus is a midbrain structure that plays important roles in visually guided behaviors in mammals. Neurons in the superior colliculus receive inputs from retinal ganglion cells but how these inputs are integrated in vivo is unknown. Here, we discovered that high-density electrodes simultaneously capture the activity of retinal axons and their postsynaptic target neurons in the superior colliculus, in vivo. We show that retinal ganglion cell axons in the mouse provide a single cell precise representation of the retina as input to superior colliculus. This isomorphic mapping builds the scaffold for precise retinotopic wiring and functionally specific connection strength. Our methods are broadly applicable, which we demonstrate by recording retinal inputs in the optic tectum in zebra finches. We find common wiring rules in mice and zebra finches that provide a precise representation of the visual world encoded in retinal ganglion cells connections to neurons in retinorecipient areas.
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spelling pubmed-94450192022-09-07 High-density electrode recordings reveal strong and specific connections between retinal ganglion cells and midbrain neurons Sibille, Jérémie Gehr, Carolin Benichov, Jonathan I. Balasubramanian, Hymavathy Teh, Kai Lun Lupashina, Tatiana Vallentin, Daniela Kremkow, Jens Nat Commun Article The superior colliculus is a midbrain structure that plays important roles in visually guided behaviors in mammals. Neurons in the superior colliculus receive inputs from retinal ganglion cells but how these inputs are integrated in vivo is unknown. Here, we discovered that high-density electrodes simultaneously capture the activity of retinal axons and their postsynaptic target neurons in the superior colliculus, in vivo. We show that retinal ganglion cell axons in the mouse provide a single cell precise representation of the retina as input to superior colliculus. This isomorphic mapping builds the scaffold for precise retinotopic wiring and functionally specific connection strength. Our methods are broadly applicable, which we demonstrate by recording retinal inputs in the optic tectum in zebra finches. We find common wiring rules in mice and zebra finches that provide a precise representation of the visual world encoded in retinal ganglion cells connections to neurons in retinorecipient areas. Nature Publishing Group UK 2022-09-05 /pmc/articles/PMC9445019/ /pubmed/36064789 http://dx.doi.org/10.1038/s41467-022-32775-2 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Sibille, Jérémie
Gehr, Carolin
Benichov, Jonathan I.
Balasubramanian, Hymavathy
Teh, Kai Lun
Lupashina, Tatiana
Vallentin, Daniela
Kremkow, Jens
High-density electrode recordings reveal strong and specific connections between retinal ganglion cells and midbrain neurons
title High-density electrode recordings reveal strong and specific connections between retinal ganglion cells and midbrain neurons
title_full High-density electrode recordings reveal strong and specific connections between retinal ganglion cells and midbrain neurons
title_fullStr High-density electrode recordings reveal strong and specific connections between retinal ganglion cells and midbrain neurons
title_full_unstemmed High-density electrode recordings reveal strong and specific connections between retinal ganglion cells and midbrain neurons
title_short High-density electrode recordings reveal strong and specific connections between retinal ganglion cells and midbrain neurons
title_sort high-density electrode recordings reveal strong and specific connections between retinal ganglion cells and midbrain neurons
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9445019/
https://www.ncbi.nlm.nih.gov/pubmed/36064789
http://dx.doi.org/10.1038/s41467-022-32775-2
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