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High-density electrode recordings reveal strong and specific connections between retinal ganglion cells and midbrain neurons
The superior colliculus is a midbrain structure that plays important roles in visually guided behaviors in mammals. Neurons in the superior colliculus receive inputs from retinal ganglion cells but how these inputs are integrated in vivo is unknown. Here, we discovered that high-density electrodes s...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9445019/ https://www.ncbi.nlm.nih.gov/pubmed/36064789 http://dx.doi.org/10.1038/s41467-022-32775-2 |
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author | Sibille, Jérémie Gehr, Carolin Benichov, Jonathan I. Balasubramanian, Hymavathy Teh, Kai Lun Lupashina, Tatiana Vallentin, Daniela Kremkow, Jens |
author_facet | Sibille, Jérémie Gehr, Carolin Benichov, Jonathan I. Balasubramanian, Hymavathy Teh, Kai Lun Lupashina, Tatiana Vallentin, Daniela Kremkow, Jens |
author_sort | Sibille, Jérémie |
collection | PubMed |
description | The superior colliculus is a midbrain structure that plays important roles in visually guided behaviors in mammals. Neurons in the superior colliculus receive inputs from retinal ganglion cells but how these inputs are integrated in vivo is unknown. Here, we discovered that high-density electrodes simultaneously capture the activity of retinal axons and their postsynaptic target neurons in the superior colliculus, in vivo. We show that retinal ganglion cell axons in the mouse provide a single cell precise representation of the retina as input to superior colliculus. This isomorphic mapping builds the scaffold for precise retinotopic wiring and functionally specific connection strength. Our methods are broadly applicable, which we demonstrate by recording retinal inputs in the optic tectum in zebra finches. We find common wiring rules in mice and zebra finches that provide a precise representation of the visual world encoded in retinal ganglion cells connections to neurons in retinorecipient areas. |
format | Online Article Text |
id | pubmed-9445019 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-94450192022-09-07 High-density electrode recordings reveal strong and specific connections between retinal ganglion cells and midbrain neurons Sibille, Jérémie Gehr, Carolin Benichov, Jonathan I. Balasubramanian, Hymavathy Teh, Kai Lun Lupashina, Tatiana Vallentin, Daniela Kremkow, Jens Nat Commun Article The superior colliculus is a midbrain structure that plays important roles in visually guided behaviors in mammals. Neurons in the superior colliculus receive inputs from retinal ganglion cells but how these inputs are integrated in vivo is unknown. Here, we discovered that high-density electrodes simultaneously capture the activity of retinal axons and their postsynaptic target neurons in the superior colliculus, in vivo. We show that retinal ganglion cell axons in the mouse provide a single cell precise representation of the retina as input to superior colliculus. This isomorphic mapping builds the scaffold for precise retinotopic wiring and functionally specific connection strength. Our methods are broadly applicable, which we demonstrate by recording retinal inputs in the optic tectum in zebra finches. We find common wiring rules in mice and zebra finches that provide a precise representation of the visual world encoded in retinal ganglion cells connections to neurons in retinorecipient areas. Nature Publishing Group UK 2022-09-05 /pmc/articles/PMC9445019/ /pubmed/36064789 http://dx.doi.org/10.1038/s41467-022-32775-2 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Sibille, Jérémie Gehr, Carolin Benichov, Jonathan I. Balasubramanian, Hymavathy Teh, Kai Lun Lupashina, Tatiana Vallentin, Daniela Kremkow, Jens High-density electrode recordings reveal strong and specific connections between retinal ganglion cells and midbrain neurons |
title | High-density electrode recordings reveal strong and specific connections between retinal ganglion cells and midbrain neurons |
title_full | High-density electrode recordings reveal strong and specific connections between retinal ganglion cells and midbrain neurons |
title_fullStr | High-density electrode recordings reveal strong and specific connections between retinal ganglion cells and midbrain neurons |
title_full_unstemmed | High-density electrode recordings reveal strong and specific connections between retinal ganglion cells and midbrain neurons |
title_short | High-density electrode recordings reveal strong and specific connections between retinal ganglion cells and midbrain neurons |
title_sort | high-density electrode recordings reveal strong and specific connections between retinal ganglion cells and midbrain neurons |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9445019/ https://www.ncbi.nlm.nih.gov/pubmed/36064789 http://dx.doi.org/10.1038/s41467-022-32775-2 |
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