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In vivo adenine base editing reverts C282Y and improves iron metabolism in hemochromatosis mice

Hemochromatosis is one of the most common inherited metabolic diseases among white populations and predominantly originates from a homozygous C282Y mutation in the HFE gene. The G > A transition at position c.845 of the gene causes misfolding of the HFE protein, ultimately resulting in its absenc...

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Detalles Bibliográficos
Autores principales:	Rovai, Alice, Chung, BoMee, Hu, Qingluan, Hook, Sebastian, Yuan, Qinggong, Kempf, Tibor, Schmidt, Florian, Grimm, Dirk, Talbot, Steven R., Steinbrück, Lars, Götting, Jasper, Bohne, Jens, Krooss, Simon A., Ott, Michael
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9445023/ https://www.ncbi.nlm.nih.gov/pubmed/36064805 http://dx.doi.org/10.1038/s41467-022-32906-9

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