Hippocampal glutathione depletion with enhanced iron level in patients with mild cognitive impairment and Alzheimer’s disease compared with healthy elderly participants

Oxidative stress has been implicated in Alzheimer’s disease, and it is potentially driven by the depletion of primary antioxidant, glutathione, as well as elevation of the pro-oxidant, iron. Present study evaluates glutathione level by magnetic resonance spectroscopy, iron deposition by quantitative...

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Detalles Bibliográficos
Autores principales: Mandal, Pravat K, Goel, Anshika, Bush, Ashley I, Punjabi, Khushboo, Joon, Shallu, Mishra, Ritwick, Tripathi, Manjari, Garg, Arun, Kumar, Natasha K, Sharma, Pooja, Shukla, Deepika, Ayton, Scott Jonathan, Fazlollahi, Amir, Maroon, Joseph C, Dwivedi, Divya, Samkaria, Avantika, Sandal, Kanika, Megha, Kanu, Shandilya, Sandhya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9445173/
https://www.ncbi.nlm.nih.gov/pubmed/36072647
http://dx.doi.org/10.1093/braincomms/fcac215

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