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The human thalamus orchestrates neocortical oscillations during NREM sleep

A hallmark of non-rapid eye movement sleep is the coordinated interplay of slow oscillations (SOs) and sleep spindles. Traditionally, a cortico-thalamo-cortical loop is suggested to coordinate these rhythms: neocortically-generated SOs trigger spindles in the thalamus that are projected back to neoc...

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Autores principales: Schreiner, Thomas, Kaufmann, Elisabeth, Noachtar, Soheyl, Mehrkens, Jan-Hinnerk, Staudigl, Tobias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9445182/
https://www.ncbi.nlm.nih.gov/pubmed/36064855
http://dx.doi.org/10.1038/s41467-022-32840-w
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author Schreiner, Thomas
Kaufmann, Elisabeth
Noachtar, Soheyl
Mehrkens, Jan-Hinnerk
Staudigl, Tobias
author_facet Schreiner, Thomas
Kaufmann, Elisabeth
Noachtar, Soheyl
Mehrkens, Jan-Hinnerk
Staudigl, Tobias
author_sort Schreiner, Thomas
collection PubMed
description A hallmark of non-rapid eye movement sleep is the coordinated interplay of slow oscillations (SOs) and sleep spindles. Traditionally, a cortico-thalamo-cortical loop is suggested to coordinate these rhythms: neocortically-generated SOs trigger spindles in the thalamus that are projected back to neocortex. Here, we used intrathalamic recordings from human epilepsy patients to test this canonical interplay. We show that SOs in the anterior thalamus precede neocortical SOs (peak −50 ms), whereas concurrently-recorded SOs in the mediodorsal thalamus are led by neocortical SOs (peak +50 ms). Sleep spindles, detected in both thalamic nuclei, preceded their neocortical counterparts (peak −100 ms) and were initiated during early phases of thalamic SOs. Our findings indicate an active role of the anterior thalamus in organizing sleep rhythms in the neocortex and highlight the functional diversity of thalamic nuclei in humans. The thalamic coordination of sleep oscillations could have broad implications for the mechanisms underlying memory consolidation.
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spelling pubmed-94451822022-09-07 The human thalamus orchestrates neocortical oscillations during NREM sleep Schreiner, Thomas Kaufmann, Elisabeth Noachtar, Soheyl Mehrkens, Jan-Hinnerk Staudigl, Tobias Nat Commun Article A hallmark of non-rapid eye movement sleep is the coordinated interplay of slow oscillations (SOs) and sleep spindles. Traditionally, a cortico-thalamo-cortical loop is suggested to coordinate these rhythms: neocortically-generated SOs trigger spindles in the thalamus that are projected back to neocortex. Here, we used intrathalamic recordings from human epilepsy patients to test this canonical interplay. We show that SOs in the anterior thalamus precede neocortical SOs (peak −50 ms), whereas concurrently-recorded SOs in the mediodorsal thalamus are led by neocortical SOs (peak +50 ms). Sleep spindles, detected in both thalamic nuclei, preceded their neocortical counterparts (peak −100 ms) and were initiated during early phases of thalamic SOs. Our findings indicate an active role of the anterior thalamus in organizing sleep rhythms in the neocortex and highlight the functional diversity of thalamic nuclei in humans. The thalamic coordination of sleep oscillations could have broad implications for the mechanisms underlying memory consolidation. Nature Publishing Group UK 2022-09-05 /pmc/articles/PMC9445182/ /pubmed/36064855 http://dx.doi.org/10.1038/s41467-022-32840-w Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Schreiner, Thomas
Kaufmann, Elisabeth
Noachtar, Soheyl
Mehrkens, Jan-Hinnerk
Staudigl, Tobias
The human thalamus orchestrates neocortical oscillations during NREM sleep
title The human thalamus orchestrates neocortical oscillations during NREM sleep
title_full The human thalamus orchestrates neocortical oscillations during NREM sleep
title_fullStr The human thalamus orchestrates neocortical oscillations during NREM sleep
title_full_unstemmed The human thalamus orchestrates neocortical oscillations during NREM sleep
title_short The human thalamus orchestrates neocortical oscillations during NREM sleep
title_sort human thalamus orchestrates neocortical oscillations during nrem sleep
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9445182/
https://www.ncbi.nlm.nih.gov/pubmed/36064855
http://dx.doi.org/10.1038/s41467-022-32840-w
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