Lower ghrelin levels does not impact the metabolic benefit induced by Roux-en-Y gastric bypass

OBJECTIVE: Roux-en-Y gastric bypass is an effective intervention for metabolic disorder. We aim to elucidate whether ghrelin contributes to weight reduction, and glycemic and lipid control after Roux-en-Y gastric bypass (RYGB). DESIGN: Four-week-old WT and Ghrl-TSC1(-/-) mice were fed high fat diet...

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Autores principales: Liang, Yuan, Yu, Ruili, He, Rui, Sun, Lijun, Luo, Chao, Feng, Lu, Chen, Hong, Yin, Yue, Zhang, Weizhen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9445200/
https://www.ncbi.nlm.nih.gov/pubmed/36082078
http://dx.doi.org/10.3389/fendo.2022.891379
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author Liang, Yuan
Yu, Ruili
He, Rui
Sun, Lijun
Luo, Chao
Feng, Lu
Chen, Hong
Yin, Yue
Zhang, Weizhen
author_facet Liang, Yuan
Yu, Ruili
He, Rui
Sun, Lijun
Luo, Chao
Feng, Lu
Chen, Hong
Yin, Yue
Zhang, Weizhen
author_sort Liang, Yuan
collection PubMed
description OBJECTIVE: Roux-en-Y gastric bypass is an effective intervention for metabolic disorder. We aim to elucidate whether ghrelin contributes to weight reduction, and glycemic and lipid control after Roux-en-Y gastric bypass (RYGB). DESIGN: Four-week-old WT and Ghrl-TSC1(-/-) mice were fed high fat diet for 12 weeks before surgery, and continued to be on the same diet for 3 weeks after surgery. Body weight, food intake, glycemic and lipid metabolism were analyzed before and after surgery. RESULTS: Gastric and circulating ghrelin was significantly increased in mice with RYGB surgery. Hypoghrelinemia elicited by deletion of TSC1 to activate mTOR signaling in gastric X/A like cells demonstrated no effect on weight reduction, glycemic and lipid control induced by Roux-en-Y gastric bypass surgery. CONCLUSION: Lower ghrelin levels does not impact the metabolic benefit induced by Roux-en-Y gastric bypass.
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spelling pubmed-94452002022-09-07 Lower ghrelin levels does not impact the metabolic benefit induced by Roux-en-Y gastric bypass Liang, Yuan Yu, Ruili He, Rui Sun, Lijun Luo, Chao Feng, Lu Chen, Hong Yin, Yue Zhang, Weizhen Front Endocrinol (Lausanne) Endocrinology OBJECTIVE: Roux-en-Y gastric bypass is an effective intervention for metabolic disorder. We aim to elucidate whether ghrelin contributes to weight reduction, and glycemic and lipid control after Roux-en-Y gastric bypass (RYGB). DESIGN: Four-week-old WT and Ghrl-TSC1(-/-) mice were fed high fat diet for 12 weeks before surgery, and continued to be on the same diet for 3 weeks after surgery. Body weight, food intake, glycemic and lipid metabolism were analyzed before and after surgery. RESULTS: Gastric and circulating ghrelin was significantly increased in mice with RYGB surgery. Hypoghrelinemia elicited by deletion of TSC1 to activate mTOR signaling in gastric X/A like cells demonstrated no effect on weight reduction, glycemic and lipid control induced by Roux-en-Y gastric bypass surgery. CONCLUSION: Lower ghrelin levels does not impact the metabolic benefit induced by Roux-en-Y gastric bypass. Frontiers Media S.A. 2022-08-23 /pmc/articles/PMC9445200/ /pubmed/36082078 http://dx.doi.org/10.3389/fendo.2022.891379 Text en Copyright © 2022 Liang, Yu, He, Sun, Luo, Feng, Chen, Yin and Zhang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Liang, Yuan
Yu, Ruili
He, Rui
Sun, Lijun
Luo, Chao
Feng, Lu
Chen, Hong
Yin, Yue
Zhang, Weizhen
Lower ghrelin levels does not impact the metabolic benefit induced by Roux-en-Y gastric bypass
title Lower ghrelin levels does not impact the metabolic benefit induced by Roux-en-Y gastric bypass
title_full Lower ghrelin levels does not impact the metabolic benefit induced by Roux-en-Y gastric bypass
title_fullStr Lower ghrelin levels does not impact the metabolic benefit induced by Roux-en-Y gastric bypass
title_full_unstemmed Lower ghrelin levels does not impact the metabolic benefit induced by Roux-en-Y gastric bypass
title_short Lower ghrelin levels does not impact the metabolic benefit induced by Roux-en-Y gastric bypass
title_sort lower ghrelin levels does not impact the metabolic benefit induced by roux-en-y gastric bypass
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9445200/
https://www.ncbi.nlm.nih.gov/pubmed/36082078
http://dx.doi.org/10.3389/fendo.2022.891379
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