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The challenging management of borderline ovarian tumors (BOTs) in women of childbearing age

Borderline ovarian tumors (BOTs) account for approximately 15% of all epithelial ovarian cancers. In 80% of cases the diagnosis of BOTs is done at stage I and more than a third of BOTs occurs in women younger than 40 years of age wishing to preserve their childbearing potential; the issue of conserv...

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Autores principales: Della Corte, Luigi, Mercorio, Antonio, Serafino, Paolo, Viciglione, Francesco, Palumbo, Mario, De Angelis, Maria Chiara, Borgo, Maria, Buonfantino, Cira, Tesorone, Marina, Bifulco, Giuseppe, Giampaolino, Pierluigi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9445208/
https://www.ncbi.nlm.nih.gov/pubmed/36081590
http://dx.doi.org/10.3389/fsurg.2022.973034
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author Della Corte, Luigi
Mercorio, Antonio
Serafino, Paolo
Viciglione, Francesco
Palumbo, Mario
De Angelis, Maria Chiara
Borgo, Maria
Buonfantino, Cira
Tesorone, Marina
Bifulco, Giuseppe
Giampaolino, Pierluigi
author_facet Della Corte, Luigi
Mercorio, Antonio
Serafino, Paolo
Viciglione, Francesco
Palumbo, Mario
De Angelis, Maria Chiara
Borgo, Maria
Buonfantino, Cira
Tesorone, Marina
Bifulco, Giuseppe
Giampaolino, Pierluigi
author_sort Della Corte, Luigi
collection PubMed
description Borderline ovarian tumors (BOTs) account for approximately 15% of all epithelial ovarian cancers. In 80% of cases the diagnosis of BOTs is done at stage I and more than a third of BOTs occurs in women younger than 40 years of age wishing to preserve their childbearing potential; the issue of conservative surgical management (fertility-sparing treatment) is thus becoming of paramount importance. At early stages, the modalities of conservative treatment could range from mono-lateral cystectomy to bilateral salpingo-oophorectomy. Although cystectomy is the preferred method to promote fertility it can lead to an elevated risk of recurrence; therefore, an appropriate counseling about the risk of relapse is mandatory before opting for this treatment. Nevertheless, relapses are often benign and can be treated by repeated conservative surgery. Besides the stage of the disease, histological subtype is another essential factor when considering the proper procedure: as most mucinous BOTs (mBOTs) are more commonly unilateral, the risk of an invasive recurrence seems to be higher, compared to serous histotype, therefore unilateral salpingo-oophorectomy is recommended. In the appraisal of current literature, this review aims to gain better insight on the current recommendations to identify the right balance between an accurate staging and an optimal fertility outcome.
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spelling pubmed-94452082022-09-07 The challenging management of borderline ovarian tumors (BOTs) in women of childbearing age Della Corte, Luigi Mercorio, Antonio Serafino, Paolo Viciglione, Francesco Palumbo, Mario De Angelis, Maria Chiara Borgo, Maria Buonfantino, Cira Tesorone, Marina Bifulco, Giuseppe Giampaolino, Pierluigi Front Surg Surgery Borderline ovarian tumors (BOTs) account for approximately 15% of all epithelial ovarian cancers. In 80% of cases the diagnosis of BOTs is done at stage I and more than a third of BOTs occurs in women younger than 40 years of age wishing to preserve their childbearing potential; the issue of conservative surgical management (fertility-sparing treatment) is thus becoming of paramount importance. At early stages, the modalities of conservative treatment could range from mono-lateral cystectomy to bilateral salpingo-oophorectomy. Although cystectomy is the preferred method to promote fertility it can lead to an elevated risk of recurrence; therefore, an appropriate counseling about the risk of relapse is mandatory before opting for this treatment. Nevertheless, relapses are often benign and can be treated by repeated conservative surgery. Besides the stage of the disease, histological subtype is another essential factor when considering the proper procedure: as most mucinous BOTs (mBOTs) are more commonly unilateral, the risk of an invasive recurrence seems to be higher, compared to serous histotype, therefore unilateral salpingo-oophorectomy is recommended. In the appraisal of current literature, this review aims to gain better insight on the current recommendations to identify the right balance between an accurate staging and an optimal fertility outcome. Frontiers Media S.A. 2022-08-23 /pmc/articles/PMC9445208/ /pubmed/36081590 http://dx.doi.org/10.3389/fsurg.2022.973034 Text en © 2022 Della Corte, Mercorio, Serafino, Viciglione, Palumbo, De Angelis, Borgo, Buonfantino, Tesorone, Bifulco and Giampaolino. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (https://creativecommons.org/licenses/by/4.0/) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Surgery
Della Corte, Luigi
Mercorio, Antonio
Serafino, Paolo
Viciglione, Francesco
Palumbo, Mario
De Angelis, Maria Chiara
Borgo, Maria
Buonfantino, Cira
Tesorone, Marina
Bifulco, Giuseppe
Giampaolino, Pierluigi
The challenging management of borderline ovarian tumors (BOTs) in women of childbearing age
title The challenging management of borderline ovarian tumors (BOTs) in women of childbearing age
title_full The challenging management of borderline ovarian tumors (BOTs) in women of childbearing age
title_fullStr The challenging management of borderline ovarian tumors (BOTs) in women of childbearing age
title_full_unstemmed The challenging management of borderline ovarian tumors (BOTs) in women of childbearing age
title_short The challenging management of borderline ovarian tumors (BOTs) in women of childbearing age
title_sort challenging management of borderline ovarian tumors (bots) in women of childbearing age
topic Surgery
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9445208/
https://www.ncbi.nlm.nih.gov/pubmed/36081590
http://dx.doi.org/10.3389/fsurg.2022.973034
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