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Visualization system based on hierarchical targeting for diagnosis and treatment of hepatocellular carcinoma
The accuracy and enrichment rate of targeted drugs largely determine the clinical diagnosis and treatment effect. Therefore, the accuracy and enrichment rate of targeted drugs should be improved. We designed a visual diagnosis and treatment system based on hierarchical targeting. It consists of mult...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9445383/ https://www.ncbi.nlm.nih.gov/pubmed/36081579 http://dx.doi.org/10.1016/j.mtbio.2022.100398 |
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author | Shi, Shasha Li, Huipu Zheng, Xi Lv, Lin Liao, Shengtao Lu, Peng Liu, Maoxia Zhao, Hongyun Mei, Zhechuan |
author_facet | Shi, Shasha Li, Huipu Zheng, Xi Lv, Lin Liao, Shengtao Lu, Peng Liu, Maoxia Zhao, Hongyun Mei, Zhechuan |
author_sort | Shi, Shasha |
collection | PubMed |
description | The accuracy and enrichment rate of targeted drugs largely determine the clinical diagnosis and treatment effect. Therefore, the accuracy and enrichment rate of targeted drugs should be improved. We designed a visual diagnosis and treatment system based on hierarchical targeting. It consists of multifunctional magnetic nanoparticles and a bio magnetic material. Bio-magnet mediated primary targeting can effectively improve the drug enrichment rate in the target tissue. SNF peptide/epithelial cell adhesion molecule antibody mediated targeting liver cancer stem cells (LCSCs) (secondary target) can improve the accuracy of the treatment and its outcomes. Low intensity focused ultrasound irradiation can explode nanoparticles around LCSCs, which can cause physical damage to cells. The combination of released interferon gamma and its receptor (tertiary target) can be used to initiate chemotherapy and immunotherapy. Using the optical properties of Fe(3)O(4) and the phase transformation ability of perfluoropentane, the system can enhance photoacoustic and ultrasonic molecular imaging enabling diagnosis and treatment visualization. Targeting LCSCs can accurately provide physical, chemical, and immune treatment of Hepatocellular carcinoma, making the therapeutic effect more effective and thorough. This system may provide a new method for a more accurate visual diagnosis and treatment of tumors. |
format | Online Article Text |
id | pubmed-9445383 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-94453832022-09-07 Visualization system based on hierarchical targeting for diagnosis and treatment of hepatocellular carcinoma Shi, Shasha Li, Huipu Zheng, Xi Lv, Lin Liao, Shengtao Lu, Peng Liu, Maoxia Zhao, Hongyun Mei, Zhechuan Mater Today Bio Full Length Article The accuracy and enrichment rate of targeted drugs largely determine the clinical diagnosis and treatment effect. Therefore, the accuracy and enrichment rate of targeted drugs should be improved. We designed a visual diagnosis and treatment system based on hierarchical targeting. It consists of multifunctional magnetic nanoparticles and a bio magnetic material. Bio-magnet mediated primary targeting can effectively improve the drug enrichment rate in the target tissue. SNF peptide/epithelial cell adhesion molecule antibody mediated targeting liver cancer stem cells (LCSCs) (secondary target) can improve the accuracy of the treatment and its outcomes. Low intensity focused ultrasound irradiation can explode nanoparticles around LCSCs, which can cause physical damage to cells. The combination of released interferon gamma and its receptor (tertiary target) can be used to initiate chemotherapy and immunotherapy. Using the optical properties of Fe(3)O(4) and the phase transformation ability of perfluoropentane, the system can enhance photoacoustic and ultrasonic molecular imaging enabling diagnosis and treatment visualization. Targeting LCSCs can accurately provide physical, chemical, and immune treatment of Hepatocellular carcinoma, making the therapeutic effect more effective and thorough. This system may provide a new method for a more accurate visual diagnosis and treatment of tumors. Elsevier 2022-08-22 /pmc/articles/PMC9445383/ /pubmed/36081579 http://dx.doi.org/10.1016/j.mtbio.2022.100398 Text en © 2022 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Full Length Article Shi, Shasha Li, Huipu Zheng, Xi Lv, Lin Liao, Shengtao Lu, Peng Liu, Maoxia Zhao, Hongyun Mei, Zhechuan Visualization system based on hierarchical targeting for diagnosis and treatment of hepatocellular carcinoma |
title | Visualization system based on hierarchical targeting for diagnosis and treatment of hepatocellular carcinoma |
title_full | Visualization system based on hierarchical targeting for diagnosis and treatment of hepatocellular carcinoma |
title_fullStr | Visualization system based on hierarchical targeting for diagnosis and treatment of hepatocellular carcinoma |
title_full_unstemmed | Visualization system based on hierarchical targeting for diagnosis and treatment of hepatocellular carcinoma |
title_short | Visualization system based on hierarchical targeting for diagnosis and treatment of hepatocellular carcinoma |
title_sort | visualization system based on hierarchical targeting for diagnosis and treatment of hepatocellular carcinoma |
topic | Full Length Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9445383/ https://www.ncbi.nlm.nih.gov/pubmed/36081579 http://dx.doi.org/10.1016/j.mtbio.2022.100398 |
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