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Bacterial nucleoid-associated protein HU as an extracellular player in host-pathogen interaction
HU protein is a member of nucleoid-associated proteins (NAPs) and is an important regulator of bacterial virulence, pathogenesis and survival. NAPs are mainly DNA structuring proteins that influence several molecular processes by binding the DNA. HU´s indispensable role in DNA-related processes in b...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9445418/ https://www.ncbi.nlm.nih.gov/pubmed/36081771 http://dx.doi.org/10.3389/fcimb.2022.999737 |
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author | Stojkova, Pavla Spidlova, Petra |
author_facet | Stojkova, Pavla Spidlova, Petra |
author_sort | Stojkova, Pavla |
collection | PubMed |
description | HU protein is a member of nucleoid-associated proteins (NAPs) and is an important regulator of bacterial virulence, pathogenesis and survival. NAPs are mainly DNA structuring proteins that influence several molecular processes by binding the DNA. HU´s indispensable role in DNA-related processes in bacteria was described. HU protein is a necessary bacterial transcription factor and is considered to be a virulence determinant as well. Less is known about its direct role in host-pathogen interactions. The latest studies suggest that HU protein may be secreted outside bacteria and be a part of the extracellular matrix. Moreover, HU protein can be internalized in a host cell after bacterial infection. Its role in the host cell is not well described and further studies are extremely needed. Existing results suggest the involvement of HU protein in host cell immune response modulation in bacterial favor, which can help pathogens resist host defense mechanisms. A better understanding of the HU protein’s role in the host cell will help to effective treatment development. |
format | Online Article Text |
id | pubmed-9445418 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-94454182022-09-07 Bacterial nucleoid-associated protein HU as an extracellular player in host-pathogen interaction Stojkova, Pavla Spidlova, Petra Front Cell Infect Microbiol Cellular and Infection Microbiology HU protein is a member of nucleoid-associated proteins (NAPs) and is an important regulator of bacterial virulence, pathogenesis and survival. NAPs are mainly DNA structuring proteins that influence several molecular processes by binding the DNA. HU´s indispensable role in DNA-related processes in bacteria was described. HU protein is a necessary bacterial transcription factor and is considered to be a virulence determinant as well. Less is known about its direct role in host-pathogen interactions. The latest studies suggest that HU protein may be secreted outside bacteria and be a part of the extracellular matrix. Moreover, HU protein can be internalized in a host cell after bacterial infection. Its role in the host cell is not well described and further studies are extremely needed. Existing results suggest the involvement of HU protein in host cell immune response modulation in bacterial favor, which can help pathogens resist host defense mechanisms. A better understanding of the HU protein’s role in the host cell will help to effective treatment development. Frontiers Media S.A. 2022-08-23 /pmc/articles/PMC9445418/ /pubmed/36081771 http://dx.doi.org/10.3389/fcimb.2022.999737 Text en Copyright © 2022 Stojkova and Spidlova https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cellular and Infection Microbiology Stojkova, Pavla Spidlova, Petra Bacterial nucleoid-associated protein HU as an extracellular player in host-pathogen interaction |
title | Bacterial nucleoid-associated protein HU as an extracellular player in host-pathogen interaction |
title_full | Bacterial nucleoid-associated protein HU as an extracellular player in host-pathogen interaction |
title_fullStr | Bacterial nucleoid-associated protein HU as an extracellular player in host-pathogen interaction |
title_full_unstemmed | Bacterial nucleoid-associated protein HU as an extracellular player in host-pathogen interaction |
title_short | Bacterial nucleoid-associated protein HU as an extracellular player in host-pathogen interaction |
title_sort | bacterial nucleoid-associated protein hu as an extracellular player in host-pathogen interaction |
topic | Cellular and Infection Microbiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9445418/ https://www.ncbi.nlm.nih.gov/pubmed/36081771 http://dx.doi.org/10.3389/fcimb.2022.999737 |
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