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Effects of omecamtiv mecarbil on the contractile properties of skinned porcine left atrial and ventricular muscles

Omecamtiv mecarbil (OM) is a novel inotropic agent for heart failure with systolic dysfunction. OM prolongs the actomyosin attachment duration, which enhances thin filament cooperative activation and accordingly promotes the binding of neighboring myosin to actin. In the present study, we investigat...

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Detalles Bibliográficos
Autores principales:	Nakanishi, Tomohiro, Oyama, Kotaro, Tanaka, Hiroyuki, Kobirumaki-Shimozawa, Fuyu, Ishii, Shuya, Terui, Takako, Ishiwata, Shin’ichi, Fukuda, Norio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Physiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9445838/ https://www.ncbi.nlm.nih.gov/pubmed/36082222 http://dx.doi.org/10.3389/fphys.2022.947206

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