Cargando…
Country data on AMR in Brazil in the context of community-acquired respiratory tract infections: links between antibiotic susceptibility, local and international antibiotic prescribing guidelines, access to medicine and clinical outcome
BACKGROUND: Antimicrobial resistance (AMR) is one of the biggest threats to global public health. Selection of resistant bacteria is driven by inappropriate use of antibiotics, amongst other factors. COVID-19 may have exacerbated AMR due to unnecessary antibiotic prescribing. Country-level knowledge...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9445857/ https://www.ncbi.nlm.nih.gov/pubmed/36065730 http://dx.doi.org/10.1093/jac/dkac215 |
_version_ | 1784783514134118400 |
---|---|
author | Torumkuney, Didem Nijhara, Puja Beltrame, Cristiana Ossaille Baisch, Elisama Queiroz Ferreira, Ricardo Macarini |
author_facet | Torumkuney, Didem Nijhara, Puja Beltrame, Cristiana Ossaille Baisch, Elisama Queiroz Ferreira, Ricardo Macarini |
author_sort | Torumkuney, Didem |
collection | PubMed |
description | BACKGROUND: Antimicrobial resistance (AMR) is one of the biggest threats to global public health. Selection of resistant bacteria is driven by inappropriate use of antibiotics, amongst other factors. COVID-19 may have exacerbated AMR due to unnecessary antibiotic prescribing. Country-level knowledge is needed to understand options for action. OBJECTIVES: To review the situation with respect to AMR in Brazil and initiatives addressing it. Identifying areas where more information is required will provide a call to action to minimize any further rises in AMR within Brazil and to improve patient outcomes. METHODS: National initiatives to address AMR, antibiotic use and prescribing in Brazil, and availability of susceptibility data, particularly for the key community-acquired respiratory tract infections (CA-RTI) pathogens Streptococcus pneumoniae and Haemophilus influenzae, were identified. National and international antibiotic prescribing guidelines for CA-RTIs (community-acquired pneumonia, acute otitis media and acute bacterial rhinosinusitis) commonly used locally were also reviewed, along with local antibiotic availability. CONCLUSIONS: In Brazil there have been some initiatives addressing AMR such as the National Action Plan for AMR, established in 2018. Antibiotic consumption in Brazil is high but a ban on over-the-counter sales of antibiotics has led to a decrease in consumption. Local antibiotic susceptibility testing needs to be increased and the Survey of Antibiotic Resistance (SOAR) study in Brazil will provide useful data for pathogens causing CA-RTIs. A more standardized inclusive approach in developing local guidelines, using up-to-date surveillance data of isolates from community-acquired infections in Brazil, could make guideline use more locally relevant for clinicians. This would pave the way for a higher level of appropriate antibiotic prescribing and improved adherence. This would, in turn, potentially limit AMR development and improve clinical outcomes for patients. |
format | Online Article Text |
id | pubmed-9445857 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-94458572022-09-06 Country data on AMR in Brazil in the context of community-acquired respiratory tract infections: links between antibiotic susceptibility, local and international antibiotic prescribing guidelines, access to medicine and clinical outcome Torumkuney, Didem Nijhara, Puja Beltrame, Cristiana Ossaille Baisch, Elisama Queiroz Ferreira, Ricardo Macarini J Antimicrob Chemother Supplement CSAR BACKGROUND: Antimicrobial resistance (AMR) is one of the biggest threats to global public health. Selection of resistant bacteria is driven by inappropriate use of antibiotics, amongst other factors. COVID-19 may have exacerbated AMR due to unnecessary antibiotic prescribing. Country-level knowledge is needed to understand options for action. OBJECTIVES: To review the situation with respect to AMR in Brazil and initiatives addressing it. Identifying areas where more information is required will provide a call to action to minimize any further rises in AMR within Brazil and to improve patient outcomes. METHODS: National initiatives to address AMR, antibiotic use and prescribing in Brazil, and availability of susceptibility data, particularly for the key community-acquired respiratory tract infections (CA-RTI) pathogens Streptococcus pneumoniae and Haemophilus influenzae, were identified. National and international antibiotic prescribing guidelines for CA-RTIs (community-acquired pneumonia, acute otitis media and acute bacterial rhinosinusitis) commonly used locally were also reviewed, along with local antibiotic availability. CONCLUSIONS: In Brazil there have been some initiatives addressing AMR such as the National Action Plan for AMR, established in 2018. Antibiotic consumption in Brazil is high but a ban on over-the-counter sales of antibiotics has led to a decrease in consumption. Local antibiotic susceptibility testing needs to be increased and the Survey of Antibiotic Resistance (SOAR) study in Brazil will provide useful data for pathogens causing CA-RTIs. A more standardized inclusive approach in developing local guidelines, using up-to-date surveillance data of isolates from community-acquired infections in Brazil, could make guideline use more locally relevant for clinicians. This would pave the way for a higher level of appropriate antibiotic prescribing and improved adherence. This would, in turn, potentially limit AMR development and improve clinical outcomes for patients. Oxford University Press 2022-09-06 /pmc/articles/PMC9445857/ /pubmed/36065730 http://dx.doi.org/10.1093/jac/dkac215 Text en © The Author(s) 2022. Published by Oxford University Press on behalf of British Society for Antimicrobial Chemotherapy. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Supplement CSAR Torumkuney, Didem Nijhara, Puja Beltrame, Cristiana Ossaille Baisch, Elisama Queiroz Ferreira, Ricardo Macarini Country data on AMR in Brazil in the context of community-acquired respiratory tract infections: links between antibiotic susceptibility, local and international antibiotic prescribing guidelines, access to medicine and clinical outcome |
title | Country data on AMR in Brazil in the context of community-acquired respiratory tract infections: links between antibiotic susceptibility, local and international antibiotic prescribing guidelines, access to medicine and clinical outcome |
title_full | Country data on AMR in Brazil in the context of community-acquired respiratory tract infections: links between antibiotic susceptibility, local and international antibiotic prescribing guidelines, access to medicine and clinical outcome |
title_fullStr | Country data on AMR in Brazil in the context of community-acquired respiratory tract infections: links between antibiotic susceptibility, local and international antibiotic prescribing guidelines, access to medicine and clinical outcome |
title_full_unstemmed | Country data on AMR in Brazil in the context of community-acquired respiratory tract infections: links between antibiotic susceptibility, local and international antibiotic prescribing guidelines, access to medicine and clinical outcome |
title_short | Country data on AMR in Brazil in the context of community-acquired respiratory tract infections: links between antibiotic susceptibility, local and international antibiotic prescribing guidelines, access to medicine and clinical outcome |
title_sort | country data on amr in brazil in the context of community-acquired respiratory tract infections: links between antibiotic susceptibility, local and international antibiotic prescribing guidelines, access to medicine and clinical outcome |
topic | Supplement CSAR |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9445857/ https://www.ncbi.nlm.nih.gov/pubmed/36065730 http://dx.doi.org/10.1093/jac/dkac215 |
work_keys_str_mv | AT torumkuneydidem countrydataonamrinbrazilinthecontextofcommunityacquiredrespiratorytractinfectionslinksbetweenantibioticsusceptibilitylocalandinternationalantibioticprescribingguidelinesaccesstomedicineandclinicaloutcome AT nijharapuja countrydataonamrinbrazilinthecontextofcommunityacquiredrespiratorytractinfectionslinksbetweenantibioticsusceptibilitylocalandinternationalantibioticprescribingguidelinesaccesstomedicineandclinicaloutcome AT beltramecristianaossaille countrydataonamrinbrazilinthecontextofcommunityacquiredrespiratorytractinfectionslinksbetweenantibioticsusceptibilitylocalandinternationalantibioticprescribingguidelinesaccesstomedicineandclinicaloutcome AT baischelisamaqueiroz countrydataonamrinbrazilinthecontextofcommunityacquiredrespiratorytractinfectionslinksbetweenantibioticsusceptibilitylocalandinternationalantibioticprescribingguidelinesaccesstomedicineandclinicaloutcome AT ferreiraricardomacarini countrydataonamrinbrazilinthecontextofcommunityacquiredrespiratorytractinfectionslinksbetweenantibioticsusceptibilitylocalandinternationalantibioticprescribingguidelinesaccesstomedicineandclinicaloutcome |