Influence of cyclic AMP on facial nerve regeneration in rats

Promoting facial nerve regeneration is a significant challenge. AIM: To evaluate the possible neurotrophic influence of cyclic AMP on facial nerve regeneration of Wistar rats. METHOD: The right facial nerve of thirty-two animals were completely transected and immediately sutured, followed by exposur...

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Detalles Bibliográficos
Autores principales: Borin, Andrei, Toledo, Ronaldo Nunes, Ho, Paulo Lee, Testa, José Ricardo Gurgel, Cruz, Oswaldo Laércio Mendonça, Fukuda, Yotaka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9445902/
https://www.ncbi.nlm.nih.gov/pubmed/19082348
http://dx.doi.org/10.1016/S1808-8694(15)31376-8
Descripción
Sumario:Promoting facial nerve regeneration is a significant challenge. AIM: To evaluate the possible neurotrophic influence of cyclic AMP on facial nerve regeneration of Wistar rats. METHOD: The right facial nerve of thirty-two animals were completely transected and immediately sutured, followed by exposure or not to topical cyclic AMP. Behavioral and histometric analyses were done at 14 and 28 days. RESULTS: Statistical differences (p<0.05) were found in the behavioral and histometric analyses on the 14th day, suggesting an early regenerative response of the facial nerve to cAMP exposure. CONCLUSION: This study demonstrates a possible neurotrophic effect of cAMP on facial nerve regeneration in rats.

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