Influence of cyclic AMP on facial nerve regeneration in rats

Promoting facial nerve regeneration is a significant challenge. AIM: To evaluate the possible neurotrophic influence of cyclic AMP on facial nerve regeneration of Wistar rats. METHOD: The right facial nerve of thirty-two animals were completely transected and immediately sutured, followed by exposur...

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Autores principales: Borin, Andrei, Toledo, Ronaldo Nunes, Ho, Paulo Lee, Testa, José Ricardo Gurgel, Cruz, Oswaldo Laércio Mendonça, Fukuda, Yotaka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9445902/
https://www.ncbi.nlm.nih.gov/pubmed/19082348
http://dx.doi.org/10.1016/S1808-8694(15)31376-8
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author Borin, Andrei
Toledo, Ronaldo Nunes
Ho, Paulo Lee
Testa, José Ricardo Gurgel
Cruz, Oswaldo Laércio Mendonça
Fukuda, Yotaka
author_facet Borin, Andrei
Toledo, Ronaldo Nunes
Ho, Paulo Lee
Testa, José Ricardo Gurgel
Cruz, Oswaldo Laércio Mendonça
Fukuda, Yotaka
author_sort Borin, Andrei
collection PubMed
description Promoting facial nerve regeneration is a significant challenge. AIM: To evaluate the possible neurotrophic influence of cyclic AMP on facial nerve regeneration of Wistar rats. METHOD: The right facial nerve of thirty-two animals were completely transected and immediately sutured, followed by exposure or not to topical cyclic AMP. Behavioral and histometric analyses were done at 14 and 28 days. RESULTS: Statistical differences (p<0.05) were found in the behavioral and histometric analyses on the 14th day, suggesting an early regenerative response of the facial nerve to cAMP exposure. CONCLUSION: This study demonstrates a possible neurotrophic effect of cAMP on facial nerve regeneration in rats.
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spelling pubmed-94459022022-09-09 Influence of cyclic AMP on facial nerve regeneration in rats Borin, Andrei Toledo, Ronaldo Nunes Ho, Paulo Lee Testa, José Ricardo Gurgel Cruz, Oswaldo Laércio Mendonça Fukuda, Yotaka Braz J Otorhinolaryngol Original Article Promoting facial nerve regeneration is a significant challenge. AIM: To evaluate the possible neurotrophic influence of cyclic AMP on facial nerve regeneration of Wistar rats. METHOD: The right facial nerve of thirty-two animals were completely transected and immediately sutured, followed by exposure or not to topical cyclic AMP. Behavioral and histometric analyses were done at 14 and 28 days. RESULTS: Statistical differences (p<0.05) were found in the behavioral and histometric analyses on the 14th day, suggesting an early regenerative response of the facial nerve to cAMP exposure. CONCLUSION: This study demonstrates a possible neurotrophic effect of cAMP on facial nerve regeneration in rats. Elsevier 2015-10-17 /pmc/articles/PMC9445902/ /pubmed/19082348 http://dx.doi.org/10.1016/S1808-8694(15)31376-8 Text en © Neck Department, Universidade Federal de Sao Paulo. https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Original Article
Borin, Andrei
Toledo, Ronaldo Nunes
Ho, Paulo Lee
Testa, José Ricardo Gurgel
Cruz, Oswaldo Laércio Mendonça
Fukuda, Yotaka
Influence of cyclic AMP on facial nerve regeneration in rats
title Influence of cyclic AMP on facial nerve regeneration in rats
title_full Influence of cyclic AMP on facial nerve regeneration in rats
title_fullStr Influence of cyclic AMP on facial nerve regeneration in rats
title_full_unstemmed Influence of cyclic AMP on facial nerve regeneration in rats
title_short Influence of cyclic AMP on facial nerve regeneration in rats
title_sort influence of cyclic amp on facial nerve regeneration in rats
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9445902/
https://www.ncbi.nlm.nih.gov/pubmed/19082348
http://dx.doi.org/10.1016/S1808-8694(15)31376-8
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