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Antihistamine promotes electroacupuncture analgesia in healthy human subjects: A pilot study
BACKGROUND AND AIM: We have previously reported that histamine H(1) receptor antagonists facilitate electroacupuncture (EA) analgesia in experimental animals. In this pilot study, we sought to determine whether the histamine H(1) receptor antagonist dexchlorpheniramine (DCPA) facilitates EA analgesi...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9446023/ https://www.ncbi.nlm.nih.gov/pubmed/36081814 http://dx.doi.org/10.1016/j.jtcme.2022.04.003 |
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author | Lee, Yu-Chen Tu, Cheng-Hao Chung, Hsin-Yi Luo, Sih-Ting Chu, Yu-Ting MacDonald, Iona J. Kotha, Peddanna Huang, Chien-Chen Lane, Hsien-Yuan Lin, Jaung-Geng Chen, Yi-Hung |
author_facet | Lee, Yu-Chen Tu, Cheng-Hao Chung, Hsin-Yi Luo, Sih-Ting Chu, Yu-Ting MacDonald, Iona J. Kotha, Peddanna Huang, Chien-Chen Lane, Hsien-Yuan Lin, Jaung-Geng Chen, Yi-Hung |
author_sort | Lee, Yu-Chen |
collection | PubMed |
description | BACKGROUND AND AIM: We have previously reported that histamine H(1) receptor antagonists facilitate electroacupuncture (EA) analgesia in experimental animals. In this pilot study, we sought to determine whether the histamine H(1) receptor antagonist dexchlorpheniramine (DCPA) facilitates EA analgesia in healthy human subjects. EXPERIMENTAL PROCEDURE: Forty healthy subjects aged 20–30 years were randomly allocated to 1 of 4 groups: (1) sham EA at acupoints Zusanli (ST36) and Yanglingquan (GB34) (sham EA; n = 10); (2) EA at ST36 and GB34 (n = 10); (3) EA at ST36 and GB34 plus low-dose DCPA (2 mg, n = 10); (4) EA at ST36 and GB34 plus high-dose DCPA (4 mg, n = 10). Before and after acupuncture treatment, pain thresholds were determined by transcutaneous electrical stimuli on the glabrous skin of the left upper arm. RESULTS: After the acupuncture session, subjects in the EA plus high-dose DCPA group had a significantly higher pain threshold elevation compared with the other 3 study groups. The change from baseline in pain threshold in the EA plus high-dose DCPA group was significantly greater than the change in pain threshold with EA only, indicating that DCPA 4 mg facilitated EA analgesia. CONCLUSION: The results suggest that combining H(1) receptor antagonist treatment with EA appears to relieve pain to a greater extent compared with EA alone. This study is registered with ClinicalTrials.gov (https://clinicaltrials.gov/), number NCT03805035 (https://clinicaltrials.gov/ct2/show/NCT03805035). |
format | Online Article Text |
id | pubmed-9446023 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-94460232022-09-07 Antihistamine promotes electroacupuncture analgesia in healthy human subjects: A pilot study Lee, Yu-Chen Tu, Cheng-Hao Chung, Hsin-Yi Luo, Sih-Ting Chu, Yu-Ting MacDonald, Iona J. Kotha, Peddanna Huang, Chien-Chen Lane, Hsien-Yuan Lin, Jaung-Geng Chen, Yi-Hung J Tradit Complement Med Article BACKGROUND AND AIM: We have previously reported that histamine H(1) receptor antagonists facilitate electroacupuncture (EA) analgesia in experimental animals. In this pilot study, we sought to determine whether the histamine H(1) receptor antagonist dexchlorpheniramine (DCPA) facilitates EA analgesia in healthy human subjects. EXPERIMENTAL PROCEDURE: Forty healthy subjects aged 20–30 years were randomly allocated to 1 of 4 groups: (1) sham EA at acupoints Zusanli (ST36) and Yanglingquan (GB34) (sham EA; n = 10); (2) EA at ST36 and GB34 (n = 10); (3) EA at ST36 and GB34 plus low-dose DCPA (2 mg, n = 10); (4) EA at ST36 and GB34 plus high-dose DCPA (4 mg, n = 10). Before and after acupuncture treatment, pain thresholds were determined by transcutaneous electrical stimuli on the glabrous skin of the left upper arm. RESULTS: After the acupuncture session, subjects in the EA plus high-dose DCPA group had a significantly higher pain threshold elevation compared with the other 3 study groups. The change from baseline in pain threshold in the EA plus high-dose DCPA group was significantly greater than the change in pain threshold with EA only, indicating that DCPA 4 mg facilitated EA analgesia. CONCLUSION: The results suggest that combining H(1) receptor antagonist treatment with EA appears to relieve pain to a greater extent compared with EA alone. This study is registered with ClinicalTrials.gov (https://clinicaltrials.gov/), number NCT03805035 (https://clinicaltrials.gov/ct2/show/NCT03805035). Elsevier 2022-04-21 /pmc/articles/PMC9446023/ /pubmed/36081814 http://dx.doi.org/10.1016/j.jtcme.2022.04.003 Text en © 2022 Center for Food and Biomolecules, National Taiwan University. Production and hosting by Elsevier Taiwan LLC. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Article Lee, Yu-Chen Tu, Cheng-Hao Chung, Hsin-Yi Luo, Sih-Ting Chu, Yu-Ting MacDonald, Iona J. Kotha, Peddanna Huang, Chien-Chen Lane, Hsien-Yuan Lin, Jaung-Geng Chen, Yi-Hung Antihistamine promotes electroacupuncture analgesia in healthy human subjects: A pilot study |
title | Antihistamine promotes electroacupuncture analgesia in healthy human subjects: A pilot study |
title_full | Antihistamine promotes electroacupuncture analgesia in healthy human subjects: A pilot study |
title_fullStr | Antihistamine promotes electroacupuncture analgesia in healthy human subjects: A pilot study |
title_full_unstemmed | Antihistamine promotes electroacupuncture analgesia in healthy human subjects: A pilot study |
title_short | Antihistamine promotes electroacupuncture analgesia in healthy human subjects: A pilot study |
title_sort | antihistamine promotes electroacupuncture analgesia in healthy human subjects: a pilot study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9446023/ https://www.ncbi.nlm.nih.gov/pubmed/36081814 http://dx.doi.org/10.1016/j.jtcme.2022.04.003 |
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