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Analysis of the TAX1BP1 gene in head and neck cancer patients
In Brazil, there were 14,160 new estimated cases of head and neck cancer for the year of 2008. Smoking and drinking are the main risk factors established in the etiology of this disease. AIM: to assess the T → A polymorphism in gene TAX1BP1 (leu306ile) in patients with head and neck cancer and a con...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9446064/ https://www.ncbi.nlm.nih.gov/pubmed/20549079 http://dx.doi.org/10.1590/S1808-86942010000200008 |
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author | Ruiz, Mariangela Torreglosa Balachi, Janayna Fernanda Fernandes, Raquel Aldrighi Galbiatti, Ana Lívia Silva Maniglia, José Victor Pavarino-Bertelli, Érika Cristina Goloni-Bertollo, Eny Maria |
author_facet | Ruiz, Mariangela Torreglosa Balachi, Janayna Fernanda Fernandes, Raquel Aldrighi Galbiatti, Ana Lívia Silva Maniglia, José Victor Pavarino-Bertelli, Érika Cristina Goloni-Bertollo, Eny Maria |
author_sort | Ruiz, Mariangela Torreglosa |
collection | PubMed |
description | In Brazil, there were 14,160 new estimated cases of head and neck cancer for the year of 2008. Smoking and drinking are the main risk factors established in the etiology of this disease. AIM: to assess the T → A polymorphism in gene TAX1BP1 (leu306ile) in patients with head and neck cancer and a control population. SERIES AND METHODS: a retrospective study in which we assessed the gender, age, smoking and drinking habits of 191 patients with head and neck cancer and 200 individuals without history of neoplasia. The molecular analysis was carried out after genomic DNA extraction by the PCR-RFLP method. RESULTS: there is a predominance of males (84.82%), smokers (91.1%) and drinkers of alcohol (77.49%). Molecular assessment did not show statistically significant differences between the two groups (p =0.32). The analysis of clinical parameters and polymorphisms showed association with oral cavity cancer (OR: 2.38; CI 95%: 1.18-4.78; p = 0.01), the other parameters were not associated with the polymorphism. CONCLUSION: There is evidence of association between TAX1BP1 gene polymorphism and oral cavity cancer. For the remaining parameters analyzed, the results do not suggest association with the TAX1BP1 gene polymorphism. |
format | Online Article Text |
id | pubmed-9446064 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-94460642022-09-09 Analysis of the TAX1BP1 gene in head and neck cancer patients Ruiz, Mariangela Torreglosa Balachi, Janayna Fernanda Fernandes, Raquel Aldrighi Galbiatti, Ana Lívia Silva Maniglia, José Victor Pavarino-Bertelli, Érika Cristina Goloni-Bertollo, Eny Maria Braz J Otorhinolaryngol Original Article In Brazil, there were 14,160 new estimated cases of head and neck cancer for the year of 2008. Smoking and drinking are the main risk factors established in the etiology of this disease. AIM: to assess the T → A polymorphism in gene TAX1BP1 (leu306ile) in patients with head and neck cancer and a control population. SERIES AND METHODS: a retrospective study in which we assessed the gender, age, smoking and drinking habits of 191 patients with head and neck cancer and 200 individuals without history of neoplasia. The molecular analysis was carried out after genomic DNA extraction by the PCR-RFLP method. RESULTS: there is a predominance of males (84.82%), smokers (91.1%) and drinkers of alcohol (77.49%). Molecular assessment did not show statistically significant differences between the two groups (p =0.32). The analysis of clinical parameters and polymorphisms showed association with oral cavity cancer (OR: 2.38; CI 95%: 1.18-4.78; p = 0.01), the other parameters were not associated with the polymorphism. CONCLUSION: There is evidence of association between TAX1BP1 gene polymorphism and oral cavity cancer. For the remaining parameters analyzed, the results do not suggest association with the TAX1BP1 gene polymorphism. Elsevier 2015-10-19 /pmc/articles/PMC9446064/ /pubmed/20549079 http://dx.doi.org/10.1590/S1808-86942010000200008 Text en . https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Original Article Ruiz, Mariangela Torreglosa Balachi, Janayna Fernanda Fernandes, Raquel Aldrighi Galbiatti, Ana Lívia Silva Maniglia, José Victor Pavarino-Bertelli, Érika Cristina Goloni-Bertollo, Eny Maria Analysis of the TAX1BP1 gene in head and neck cancer patients |
title | Analysis of the TAX1BP1 gene in head and neck cancer patients |
title_full | Analysis of the TAX1BP1 gene in head and neck cancer patients |
title_fullStr | Analysis of the TAX1BP1 gene in head and neck cancer patients |
title_full_unstemmed | Analysis of the TAX1BP1 gene in head and neck cancer patients |
title_short | Analysis of the TAX1BP1 gene in head and neck cancer patients |
title_sort | analysis of the tax1bp1 gene in head and neck cancer patients |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9446064/ https://www.ncbi.nlm.nih.gov/pubmed/20549079 http://dx.doi.org/10.1590/S1808-86942010000200008 |
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